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Meta-Analysis
. 2023 May 12;23(1):284.
doi: 10.1186/s12903-023-03031-w.

Periostin level in gingival crevicular fluid in periodontal disease: a systematic review and meta-analysis

Fatemeh Abdolalian #  1 , Mojtaba Bayani #  1 , Saeid Afzali  2 , Afrooz Nakhostin  3 , Amir Almasi-Hashiani  4   5
Affiliations
Meta-Analysis

Periostin level in gingival crevicular fluid in periodontal disease: a systematic review and meta-analysis

Fatemeh Abdolalian et al. BMC Oral Health. .

Abstract

Background: Periostin, a secreted adhesion molecule, is a matricellular protein secreted most in periodontal ligament and periosteum. Periostin is also needed for integrity and maturation of periodontal tissue. This meta-analysis was conducted to compare the gingival crevicular fluid (GCF) periostin levels in subjects having periodontal disease and healthy periodontium.

Methods: In this meta-analysis, three international database including PubMed, Scopus and Web of Science were searched and 207 studies retrieved. Also, the Google Scholar was searched to find more related studies (two studies were found). To assess the risk of bias of included studies, the Newcastle-Ottawa assessment scale adapted for case-control was used. Finally, required data was extracted and included into analysis. All statistical analysis were done using Stata software.

Results: Eight studies were included in this meta-analysis. Results showed that GCF periostin level is significant lower in chronic periodontitis group compare to healthy people (the standardized mean difference (SMD) = -3.15, 95% CI = -4.45, -1.85, p < 0.001). The syntheses of studies shown a significant decrease in the periostin level of chronic periodontitis patients compared to the gingivitis patients (SMD = -1.50, 95%CI = -2.52, -0.49, P = 0.003), while the mean level of periostin between the gingivitis patients and healthy group has no significant difference (SMD = -0.88, 95%CI = -2.14, 0.38, P = 0.173).

Conclusion: The mean concentration of GCF periostin in people with chronic periodontitis significantly decreased compared to people with gingivitis and also compared to healthy people, while no significant difference was observed between the two groups with gingivitis and healthy people. Therefore, this marker may be used as a diagnostic criterion for the disease, which requires further studies.

Keywords: Gingival Crevicular fluid; Meta-analysis; Periodontal disease; Periostin; Systematic review.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flow diagram of the literature search for studies included in meta-analysis
Fig. 2
Fig. 2
Forest plot comparing the GCF periostin level of chronic periodontitis patients and healthy individuals
Fig. 3
Fig. 3
Forest plot comparing the GCF periostin level of chronic periodontitis patients and gingivitis patients
Fig. 4
Fig. 4
Forest plot comparing the GCF periostin level in gingivitis patients and healthy individuals
See this image and copyright information in PMC

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