Randomized Controlled Trial

. 2023 May 12;18(1):29.

doi: 10.1186/s13722-023-00388-9.

Integrated smoking cessation and mood management following acute coronary syndrome: Protocol for the post-acute cardiac event smoking (PACES) trial

Melissa Adkins-Hempel¹, Sandra J Japuntich^{1

2

3}, Michelle Chrastek¹, Shira Dunsiger^{4

5}, Christopher E Breault⁶, Woubeshet Ayenew^{7

8}, Susan A Everson-Rose^{3

9}, Prabhjot S Nijjar⁸, Beth C Bock^{6

10}, Wen-Chih Wu^{5

11

12}, Michael D Miedema¹³, Brett M Carlson¹⁴, Andrew M Busch^{15

16

17

18}

Affiliations

¹ Behavioral Health Equity Research Group, Hennepin Healthcare Research Institute, 701 Park Ave. S9.104, Minneapolis, MN, 55415, USA.
² Division of Clinical Pharmacology, Department of Medicine, Hennepin Healthcare, 900 S. 8th St., G5, Minneapolis, MN, 55415, USA.
³ Division of General Internal Medicine, Department of Medicine, University of Minnesota, 401 East River Parkway, Suite 131, Minneapolis, MN, 55455, USA.
⁴ Department of Behavioral and Social Sciences, Center for Health Promotion and Health Equity, School of Public Health, Brown University, 121 South Main St., Providence, RI, 02903, USA.
⁵ Department of Epidemiology, School of Public Health, Brown University, 121 South Main St., Providence, RI, 02903, USA.
⁶ Center for Behavioral and Preventative Medicine, Lifespan, 1 Hoppin St., Suite 309, Providence, RI, 02903, USA.
⁷ Division of Cardiology, Department of Medicine, Hennepin Healthcare, 900 South 8th St., O5, Minneapolis, MN, 55415, USA.
⁸ Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, 420 Delaware Street SE, MMC 508, Minneapolis, MN, 55455, USA.
⁹ Program in Health Disparities Research, University of Minnesota, 717 Delaware St. SE, Suite 166, Minneapolis, MN, 55414, USA.
¹⁰ Department of Psychiatry and Human Behavior, Alpert School of Medicine, Brown University, 700 Butler Drive, Providence, RI, 02906, USA.
¹¹ Center of Innovation in Long Term Services and Support, Providence VA Medical Center, 830 Chalkstone Ave., Providence, RI, 02908, USA.
¹² Cardiovascular Rehab Center, Lifespan, 208 Collyer St., Providence, RI, 02904, USA.
¹³ Minneapolis Heart Institute and Minneapolis Heart Institute Foundation, 920 East 28th St., Suite 480, Minneapolis, MN, 55407, USA.
¹⁴ North Memorial Health Heart and Vascular Center, 3300 Oakdale Ave. N., Suite 200, Robbinsdale, MN, 55422, USA.
¹⁵ Behavioral Health Equity Research Group, Hennepin Healthcare Research Institute, 701 Park Ave. S9.104, Minneapolis, MN, 55415, USA. Andrew.Busch@hcmed.org.
¹⁶ Division of Clinical Pharmacology, Department of Medicine, Hennepin Healthcare, 900 S. 8th St., G5, Minneapolis, MN, 55415, USA. Andrew.Busch@hcmed.org.
¹⁷ Division of General Internal Medicine, Department of Medicine, University of Minnesota, 401 East River Parkway, Suite 131, Minneapolis, MN, 55455, USA. Andrew.Busch@hcmed.org.
¹⁸ Program in Health Disparities Research, University of Minnesota, 717 Delaware St. SE, Suite 166, Minneapolis, MN, 55414, USA. Andrew.Busch@hcmed.org.

PMID: 37173792
PMCID: PMC10175930
DOI: 10.1186/s13722-023-00388-9

Randomized Controlled Trial

Integrated smoking cessation and mood management following acute coronary syndrome: Protocol for the post-acute cardiac event smoking (PACES) trial

Melissa Adkins-Hempel et al. Addict Sci Clin Pract. 2023.

. 2023 May 12;18(1):29.

doi: 10.1186/s13722-023-00388-9.

Authors

Affiliations

¹ Behavioral Health Equity Research Group, Hennepin Healthcare Research Institute, 701 Park Ave. S9.104, Minneapolis, MN, 55415, USA.
² Division of Clinical Pharmacology, Department of Medicine, Hennepin Healthcare, 900 S. 8th St., G5, Minneapolis, MN, 55415, USA.
³ Division of General Internal Medicine, Department of Medicine, University of Minnesota, 401 East River Parkway, Suite 131, Minneapolis, MN, 55455, USA.
⁴ Department of Behavioral and Social Sciences, Center for Health Promotion and Health Equity, School of Public Health, Brown University, 121 South Main St., Providence, RI, 02903, USA.
⁵ Department of Epidemiology, School of Public Health, Brown University, 121 South Main St., Providence, RI, 02903, USA.
⁶ Center for Behavioral and Preventative Medicine, Lifespan, 1 Hoppin St., Suite 309, Providence, RI, 02903, USA.
⁷ Division of Cardiology, Department of Medicine, Hennepin Healthcare, 900 South 8th St., O5, Minneapolis, MN, 55415, USA.
⁸ Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, 420 Delaware Street SE, MMC 508, Minneapolis, MN, 55455, USA.
⁹ Program in Health Disparities Research, University of Minnesota, 717 Delaware St. SE, Suite 166, Minneapolis, MN, 55414, USA.
¹⁰ Department of Psychiatry and Human Behavior, Alpert School of Medicine, Brown University, 700 Butler Drive, Providence, RI, 02906, USA.
¹¹ Center of Innovation in Long Term Services and Support, Providence VA Medical Center, 830 Chalkstone Ave., Providence, RI, 02908, USA.
¹² Cardiovascular Rehab Center, Lifespan, 208 Collyer St., Providence, RI, 02904, USA.
¹³ Minneapolis Heart Institute and Minneapolis Heart Institute Foundation, 920 East 28th St., Suite 480, Minneapolis, MN, 55407, USA.
¹⁴ North Memorial Health Heart and Vascular Center, 3300 Oakdale Ave. N., Suite 200, Robbinsdale, MN, 55422, USA.
¹⁵ Behavioral Health Equity Research Group, Hennepin Healthcare Research Institute, 701 Park Ave. S9.104, Minneapolis, MN, 55415, USA. Andrew.Busch@hcmed.org.
¹⁶ Division of Clinical Pharmacology, Department of Medicine, Hennepin Healthcare, 900 S. 8th St., G5, Minneapolis, MN, 55415, USA. Andrew.Busch@hcmed.org.
¹⁷ Division of General Internal Medicine, Department of Medicine, University of Minnesota, 401 East River Parkway, Suite 131, Minneapolis, MN, 55455, USA. Andrew.Busch@hcmed.org.
¹⁸ Program in Health Disparities Research, University of Minnesota, 717 Delaware St. SE, Suite 166, Minneapolis, MN, 55414, USA. Andrew.Busch@hcmed.org.

PMID: 37173792
PMCID: PMC10175930
DOI: 10.1186/s13722-023-00388-9

Abstract

Background: Approximately 400,000 people who smoke cigarettes survive Acute Coronary Syndrome (ACS; unstable angina, ST and non-ST elevation myocardial infarction) each year in the US. Continued smoking following ACS is an independent predictor of mortality. Depressed mood post-ACS is also predictive of mortality, and smokers with depressed mood are less likely to abstain from smoking following an ACS. A single, integrated treatment targeting depressed mood and smoking could be effective in reducing post-ACS mortality.

Method/design: The overall aim of the current study is to conduct a fully powered efficacy trial enrolling 324 smokers with ACS and randomizing them to 12 weeks of an integrated smoking cessation and mood management treatment [Behavioral Activation Treatment for Cardiac Smokers (BAT-CS)] or control (smoking cessation and general health education). Both groups will be offered 8 weeks of the nicotine patch if medically cleared. Counseling in both arms will be provided by tobacco treatment specialists. Follow-up assessments will be conducted at end-of-treatment (12-weeks) and 6, 9, and 12 months after hospital discharge. We will track major adverse cardiac events and all-cause mortality for 36 months post-discharge. Primary outcomes are depressed mood and biochemically validated 7-day point prevalence abstinence from smoking over 12 months.

Discussion: Results of this study will inform smoking cessation treatments post-ACS and provide unique data on the impact of depressed mood on success of post-ACS health behavior change attempts.

Trial registration: ClinicalTrials.gov, NCT03413423. Registered 29 January 2018. https://beta.

Clinicaltrials: gov/study/NCT03413423 .

Keywords: Acute coronary syndrome; Behavioral activation; Cardiovascular disease; Depression; Secondary prevention; Smoking.

PubMed Disclaimer

Conflict of interest statement

All authors declare that they have no competing interests.

Figures

See this image and copyright information in PMC

References

1. Tsao CW, Aday AW, Almarzooq ZI, et al. Heart disease and stroke statistics—2022 update: a report from the american heart association. Circulation. 2022;145(8):1. 10.1161/CIR.0000000000001052. - PubMed
1. Khot UN, Khot MB, Bajzer CT, et al. Prevalence of conventional risk factors in patients with coronary heart disease. JAMA. 2003;290(7):898–904. doi: 10.1001/jama.290.7.898. - DOI - PubMed
1. Shahoumian TA, Phillips BR, Backus LI. Cigarette smoking, reduction and quit attempts: prevalence among veterans with coronary heart disease. Prev Chronic Dis. 2016;13:150282. 10.5888/pcd13.150282 - PMC - PubMed
1. McBride CM, Emmons KM, Lipkus IM. Understanding the potential of teachable moments: the case of smoking cessation. Health Educ Res. 2003;18(2):156–170. doi: 10.1093/her/18.2.156. - DOI - PubMed
1. Critchley JA, Capewell S. Mortality risk reduction associated with smoking cessation in patients with coronary heart disease: a systematic review. JAMA. 2003;290(1):86–97. doi: 10.1001/jama.290.1.86. - DOI - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions

Associated data

Actions
- Search in PubMed
- Search in ClinicalTrials.gov

Grants and funding

R01 HL136327/HL/NHLBI NIH HHS/United States

LinkOut - more resources

Full Text Sources
Medical
- ClinicalTrials.gov
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Integrated smoking cessation and mood management following acute coronary syndrome: Protocol for the post-acute cardiac event smoking (PACES) trial

Affiliations

Integrated smoking cessation and mood management following acute coronary syndrome: Protocol for the post-acute cardiac event smoking (PACES) trial

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Associated data

Grants and funding

LinkOut - more resources

Full Text Sources

Medical