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. 2023 Apr 28;15(9):2531.
doi: 10.3390/cancers15092531.

CD19 (+) B Cell Combined with Prognostic Nutritional Index Predicts the Clinical Outcomes of Patients with Gastric Cancer Who Underwent Surgery

Hao Sun  1 , Huibo Wang  1 , Hongming Pan  1 , Yanjiao Zuo  1 , Ruihu Zhao  1 , Rong Huang  1 , Yingwei Xue  1 , Hongjiang Song  1
Affiliations

CD19 (+) B Cell Combined with Prognostic Nutritional Index Predicts the Clinical Outcomes of Patients with Gastric Cancer Who Underwent Surgery

Hao Sun et al. Cancers (Basel). .

Abstract

(1) Background: The aim of this study was to explore the predictive ability of lymphocyte subsets for the prognosis of gastric cancer patients who underwent surgery and the prognostic value of CD19 (+) B cell combined with the Prognostic Nutritional Index (PNI). (2) Methods: This study involved 291 patients with gastric cancer who underwent surgery at our institution between January 2016 and December 2017. All patients had complete clinical data and peripheral lymphocyte subsets. Differences in clinical and pathological characteristics were examined using the Chi-square test or independent sample t-tests. The difference in survival was evaluated using Kaplan-Meier survival curves and the Log-rank test. Cox's regression analysis was performed to identify independent prognostic indicators, and nomograms were used to predict survival probabilities. (3) Results: Patients were categorized into three groups based on their CD19 (+) B cell and PNI levels, with 56 cases in group one, 190 cases in group two, and 45 cases in group three. Patients in group one had a shorter progression-free survival (PFS) (HR = 0.444, p < 0.001) and overall survival (OS) (HR = 0.435, p < 0.001). CD19 (+) B cell-PNI had the highest area under the curve (AUC) compared with other indicators, and it was also identified as an independent prognostic factor. Moreover, CD3 (+) T cell, CD3 (+) CD8 (+) T cell, and CD3 (+) CD16 (+) CD56 (+) NK T cell were all negatively correlated with the prognosis, while CD19 (+) B cell was positively associated with the prognosis. The C-index and 95% confidence interval (CI) of nomograms for PFS and OS were 0.772 (0.752-0.833) and 0.773 (0.752-0.835), respectively. (4) Conclusions: Lymphocyte subsets including CD3 (+) T cell, CD3 (+) CD8 (+) T cell, CD3 (+) CD16 (+) CD56 (+) NK T cell, and CD19 (+) B cell were related to the clinical outcomes of patients with gastric cancer who underwent surgery. Additionally, PNI combined with CD19 (+) B cell had higher prognostic value and could be used to identify patients with a high risk of metastasis and recurrence after surgery.

Keywords: gastric cancer; peripheral lymphocyte subsets; prognostic factor; prognostic nutritional index; surgery.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The ROC curve of (A) CD3 (+) T cell, (B) CD3 (+) CD8 (+) T cell, (C) CD19 (+) B cell, (D) CD3 (+) CD16 (+) CD56 (+) NK T cell, (E) ALB, (F) Lym, and (G) PNI.
Figure 2
Figure 2
Survival curve for lymphocyte subset. CD3 (+)-related survival curve for (A) PFS and (B) OS; CD3 (+) CD8 (+)-related survival curve for (C) PFS and (D) OS; CD19 (+)-related survival curve for (E) PFS and (F) OS. CD3 (+) CD16 (+) CD56 (+)-related survival curve for (G) PFS and (H) OS.
Figure 3
Figure 3
Survival curve for Prognostic Nutritional Index. ALB-related survival curve for (A) PFS and (B) OS; Lym-related survival curve for (C) PFS and (D) OS; PNI-related survival curve for (E) PFS and (F) OS.
Figure 4
Figure 4
The ROC curve and AUC of grouped CD19 (+) B cell–PNI-related factors.
Figure 5
Figure 5
CD19 (+) B cell–PNI-related survival curve of (A) PFS and (B) OS.
Figure 6
Figure 6
CD19 (+) B cell–PNI-related survival curves in different TNM stages. TNM-stage-related survival curve for PFS (A) and OS (B); CD19 (+) B cell–PNI-related survival curves in TNM stages I and II for PFS (C) and OS (D); CD19 (+) B cell–PNI-related survival curves in TNM stages III and IV for PFS (E) and OS (F).
Figure 7
Figure 7
Nomograms of (A) PFS and (B) OS.
Figure 8
Figure 8
The calibration curves of the nomograms for (A) PFS and (B) OS.
See this image and copyright information in PMC

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