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Review
. 2023 May 6;15(9):2639.
doi: 10.3390/cancers15092639.

Updated Epidemiology of Gastric Cancer in Asia: Decreased Incidence but Still a Big Challenge

Wing Sum Shin  1 , Fuda Xie  1   2   3 , Bonan Chen  1   2   3 , Peiyao Yu  4 , Jun Yu  2   5 , Ka Fai To  1   2 , Wei Kang  1   2   3
Affiliations
Review

Updated Epidemiology of Gastric Cancer in Asia: Decreased Incidence but Still a Big Challenge

Wing Sum Shin et al. Cancers (Basel). .

Abstract

Despite the decline in incidence and mortality rates, gastric cancer (GC) is the fifth leading cause of cancer deaths worldwide. The incidence and mortality of GC are exceptionally high in Asia due to high H. pylori infection, dietary habits, smoking behaviors, and heavy alcohol consumption. In Asia, males are more susceptible to developing GC than females. Variations in H. pylori strains and prevalence rates may contribute to the differences in incidence and mortality rates across Asian countries. Large-scale H. pylori eradication was one of the effective ways to reduce GC incidences. Treatment methods and clinical trials have evolved, but the 5-year survival rate of advanced GC is still low. Efforts should be put towards large-scale screening and early diagnosis, precision medicine, and deep mechanism studies on the interplay of GC cells and microenvironments for dealing with peritoneal metastasis and prolonging patients' survival.

Keywords: H. pylori; gastric cancer; incidence; mortality; targeted therapy.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The age-standardized incidence rates of GC in different regions.
Figure 2
Figure 2
The age-standardized incidence rates of gastric carcinoma for men and women in different countries of Asia in 2020.
Figure 3
Figure 3
GC age-standardized mortality rate in China between urban and rural areas from 2012 to 2016.
Figure 4
Figure 4
The age-standardized incidence rates of stomach cancer for both sexes from 1975 to 2019 in Japan.
Figure 5
Figure 5
Top 10 age-standardized rates of GC per 100,000 in the leading countries in 2020.
Figure 6
Figure 6
The incidence rates of H. pylori infection in different Asia-Pacific regions; China, Japan, Republic of Korea, Vietnam, Malaysia, Hong Kong, and Mongolia.
Figure 7
Figure 7
Age-standardized rate of GC from 1999 to 2020 in Republic of Korea.
Figure 8
Figure 8
Age-specific rate of GC in both sexes of Republic of Korea in 2020.
Figure 9
Figure 9
The incidence rates of gastric carcinoma in both sexes among different age groups in Hong Kong.
Figure 10
Figure 10
The age-standardized incidence rates (per 100,000) of GC in Hong Kong from 1983 to 2020.
See this image and copyright information in PMC

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