Gut Microbiota and Behavioural Issues in Production, Performance, and Companion Animals: A Systematic Review

Abstract

The literature has identified poor nutrition as the leading factor in the manifestation of many behavioural issues in animals, including aggression, hyperalertness, and stereotypies. Literature focused on all species of interest consistently reported that although there were no significant differences in the richness of specific bacterial taxa in the microbiota of individual subjects with abnormal behaviour (termed alpha diversity), there was variability in species diversity between these subjects compared to controls (termed beta diversity). As seen in humans with mental disorders, animals exhibiting abnormal behaviour often have an enrichment of pro-inflammatory and lactic acid-producing bacteria and a reduction in butyrate-producing bacteria. It is evident from the literature that an association exists between gut microbiota diversity (and by extension, the concurrent production of microbial metabolites) and abnormal behavioural phenotypes across various species, including pigs, dogs, and horses. Similar microbiota population changes are also evident in human mental health patients. However, there are insufficient data to identify this association as a cause or effect. This review provides testable hypotheses for future research to establish causal relationships between gut microbiota and behavioural issues in animals, offering promising potential for the development of novel therapeutic and/or preventative interventions aimed at restoring a healthy gut-brain-immune axis to mitigate behavioural issues and, in turn, improve health, performance, and production in animals.

Keywords: animals; behaviour; microbiome.

Figure 1

Number of references reporting increase or decrease in the levels of Firmicutes, Protobacteria, Bacteriodetes, and Actinobacteria with depression, anxiety, bipolar disorder, schizophrenia, tail bitten, tail bitter, unresponsive, aggressive, alert, oral stereotypies, locomotion stereotypies, phobic, and aggressive in four selected species: human (A), porcine (B), equine (C), and canine (D).