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Review
. 2023 Apr 24;13(9):1528.
doi: 10.3390/diagnostics13091528.

Acute Respiratory Distress Syndrome; A Review of Recent Updates and a Glance into the Future

Husayn F Ramji  1   2 , Maida Hafiz  3 , Hiba Hammad Altaq  4 , Syed Talal Hussain  4 , Fawad Chaudry  4
Affiliations
Review

Acute Respiratory Distress Syndrome; A Review of Recent Updates and a Glance into the Future

Husayn F Ramji et al. Diagnostics (Basel). .

Abstract

Acute respiratory distress syndrome (ARDS) is a rapidly progressive form of respiratory failure that accounts for 10% of admissions to the ICU and is associated with approximately 40% mortality in severe cases. Despite significant mortality and healthcare burden, the mainstay of management remains supportive care. The recent pandemic of SARS-CoV-2 has re-ignited a worldwide interest in exploring the pathophysiology of ARDS, looking for innovative ideas to treat this disease. Recently, many trials have been published utilizing different pharmacotherapy targets; however, the long-term benefits of these agents remain unknown. Metabolomics profiling and stem cell transplantation offer strong enthusiasm and may completely change the outlook of ARDS management in the near future.

Keywords: acute respiratory distress syndrome; gut-lung microbiome; mesenchymal stem cell transplantation; metabolomics; pharmacotherapy in ARDS.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The concept of “Omics” in scientific research. Metabolomics is the newest addition, focusing on analyzing low molecular weight compounds. DNA = Deoxyribonucleic acid, RNA = Ribonucleic acid.
See this image and copyright information in PMC

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References

    1. Barry J.M. The site of origin of the 1918 influenza pandemic and its public health implications. J. Transl. Med. 2004;2:3. doi: 10.1186/1479-5876-2-3. - DOI - PMC - PubMed
    1. Oxford J.S. The so-called Great Spanish Influenza Pandemic of 1918 may have originated in France in 1916. Philos. Trans. R. Soc. B Biol. Sci. 2001;356:1857–1859. doi: 10.1098/rstb.2001.1012. - DOI - PMC - PubMed
    1. Rezoagli E., Fumagalli R., Bellani G. Definition and epidemiology of acute respiratory distress syndrome. Ann. Transl. Med. 2017;5:282. doi: 10.21037/atm.2017.06.62. - DOI - PMC - PubMed
    1. Diamond M., Peniston H.L., Sanghavi D., Mahapatra S. Acute Respiratory Distress Syndrome. StatPearls Publishing; Tampa, FL, USA: 2022. - PubMed
    1. Ashbaugh D., Bigelow D.B., Petty T., Levine B., Ashbaugh D., Bigelow D.B., Petty T., Levine B. Acute Respiratory Distress in Adults. Lancet. 1967;2:319–323. doi: 10.1016/S0140-6736(67)90168-7. - DOI - PubMed

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