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. 2023 Apr 23;28(9):3671.
doi: 10.3390/molecules28093671.

Anticancer Potentials of the Lignan Magnolin: A Systematic Review

Md Shimul Bhuia  1 , Polrat Wilairatana  2 , Raihan Chowdhury  1 , Asraful Islam Rakib  1 , Hossam Kamli  3 , Ahmad Shaikh  3 , Henrique D M Coutinho  4 , Muhammad Torequl Islam  1
Affiliations

Anticancer Potentials of the Lignan Magnolin: A Systematic Review

Md Shimul Bhuia et al. Molecules. .

Abstract

Magnolin is a naturally occurring, multi-bioactive lignan molecule with inherent anticancer effects. This study aims to summarize the botanical origins and anticancer properties of magnolin. For this, a recent (as of March 2023) literature review was conducted using various academic search engines, including PubMed, Springer Link, Wiley Online, Web of Science, Science Direct, and Google Scholar. All the currently available information about this phytochemical and its role in various cancer types has been gathered and investigated. Magnolin is a compound found in many different plants. It has been demonstrated to have anticancer activity in numerous experimental models by inhibiting the cell cycle (G1 and G2/M phase); inducing apoptosis; and causing antiinvasion, antimetastasis, and antiproliferative effects via the modulation of several pathways. In conclusion, magnolin showed robust anticancer activity against many cancer cell lines by altering several cancer signaling pathways in various non- and pre-clinical experimental models, making it a promising plant-derived chemotherapeutic option for further clinical research.

Keywords: biological sources; cancer cell lines; lignan; magnolin; pharmacokinetic profile.

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Conflict of interest statement

The authors state that they have no conflict of interest to disclose.

Figures

Figure 1
Figure 1
(a) Two-dimensional chemical structure of magnolin and (b) different pharmacological activities of magnolin based on literature.
Figure 2
Figure 2
Schematic presentation of data collection, inclusion and exclusion criteria (PM: PubMed; SD: Science Direct; MS: miscellaneous (e.g., Google Scholar and Research Gate)).
Figure 3
Figure 3
Anticancer mechanisms of magnolin.
See this image and copyright information in PMC

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