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Review
. 2023 Apr 24;24(9):7767.
doi: 10.3390/ijms24097767.

SIGMAR1 Confers Innate Resilience against Neurodegeneration

Simon Couly  1 , Yuko Yasui  1 , Tsung-Ping Su  1
Affiliations
Review

SIGMAR1 Confers Innate Resilience against Neurodegeneration

Simon Couly et al. Int J Mol Sci. .

Abstract

The sigma-1 receptor (SIGMAR1) is one of a kind: a receptor chaperone protein. This 223 amino acid-long protein is enriched at the mitochondria-associated endoplasmic reticulum membrane (MAM), a specialized microdomain of the endoplasmic reticulum that is structurally and functionally connected to the mitochondria. As a receptor, SIGMAR1 binds a wide spectrum of ligands. Numerous molecules targeting SIGMAR1 are currently in pre-clinical or clinical development. Interestingly, the range of pathologies covered by these studies is broad, especially with regard to neurodegenerative disorders. Upon activation, SIGMAR1 can translocate and interact with other proteins, mostly at the MAM but also in other organelles, which allows SIGMAR1 to affect many cellular functions. During these interactions, SIGMAR1 exhibits chaperone protein behavior by participating in the folding and stabilization of its partner. In this short communication, we will shed light on how SIGMAR1 confers protection against neurodegeneration to the cells of the nervous system and why this ability makes SIGMAR1 a multifunctional therapeutic prospect.

Keywords: Sigma-1 receptor; mitochondria-associated endoplasmic reticulum membrane (MAM); neurodegenerative disorders.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Innate resilience provided by SIGMAR1 from head to tail against neurodegeneration [4,22,26,39,47,48,52,61,62,64,66,68,69,70,71,72,75,78].
See this image and copyright information in PMC

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