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Editorial
. 2023 Apr 28;24(9):7974.
doi: 10.3390/ijms24097974.

The Toxicity of Protein Aggregates: New Insights into the Mechanisms

Alessandra Bigi  1 , Eva Lombardo  1 , Roberta Cascella  1 , Cristina Cecchi  1
Affiliations
Editorial

The Toxicity of Protein Aggregates: New Insights into the Mechanisms

Alessandra Bigi et al. Int J Mol Sci. .

Abstract

The aberrant aggregation of specific peptides and proteins is the common feature of a range of more than 50 human pathologies, collectively referred to as protein misfolding diseases [...].

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Conflict of interest statement

The authors declare that there are no conflict of interest.

Figures

Figure 1
Figure 1
Overview of the main topics developed in the Special Issue. Adapted from Limbocker et al. [9] and Kreiser et al. [11].
See this image and copyright information in PMC

References

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    1. Bigi A., Cascella R., Chiti F., Cecchi C. Amyloid fibrils act as a reservoir of soluble oligomers, the main culprits in protein deposition diseases. Bioessays. 2022;44:e2200086. doi: 10.1002/bies.202200086. - DOI - PubMed
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    1. Bigi A., Ermini E., Chen S.W., Cascella R., Cecchi C. Exploring the release of toxic oligomers from α-synuclein fibrils with Antibodies and STED microscopy. Life. 2021;11:431. doi: 10.3390/life11050431. - DOI - PMC - PubMed

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