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Review
. 2023 Apr 28;24(9):7981.
doi: 10.3390/ijms24097981.

Bridging the Gap in Cancer-Related Stroke Management: Update on Therapeutic and Preventive Approaches

Ming-Yee Sun  1   2   3 , Sonu M M Bhaskar  1   2   4   5   6
Affiliations
Review

Bridging the Gap in Cancer-Related Stroke Management: Update on Therapeutic and Preventive Approaches

Ming-Yee Sun et al. Int J Mol Sci. .

Abstract

The underlying aetiopathophysiology of cancer-related strokes and thromboembolisms differs from that of noncancer-related strokes, which makes treating cancer-related strokes and thromboembolisms a distinct clinical challenge. This necessitates the development of novel, individualised diagnostic and treatment strategies. However, limited guidelines are available for the management of cancer-related strokes and the prevention of acute strokes or other thromboembolic events in this patient population. In this article, we present an updated overview of the therapeutic and preventive strategies for strokes in cancer settings. These strategies include acute reperfusion therapy, anticoagulant therapy, antiplatelet therapy, and lifestyle management options. We also outline comprehensive pathways and highlight gaps in the evidence-based clinical management of cancer-related strokes or thromboembolisms. Additionally, future recommendations for the management of strokes in cancer patients are provided.

Keywords: anticoagulation; cancer; cerebrovascular disorders; prevention; reperfusion; stroke; thromboembolism.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Recommendations for future practice in the management of stroke in cancer patients. Abbreviations: DVT: deep venous thrombosis; PE: pulmonary embolism; VTE: venous thromboembolism; DOAC: direct-acting oral anticoagulant; LMWH: low-molecular-weight heparin; GI: gastrointestinal.
See this image and copyright information in PMC

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