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. 2023 Apr 25;12(9):3108.
doi: 10.3390/jcm12093108.

Supine MDS-UPDRS-III Assessment: An Explorative Study

Naomi I Kremer  1 , Annemarie Smid  1 , Stèfan F Lange  1 , Iara Mateus Marçal  1 , Katalin Tamasi  1   2 , J Marc C van Dijk  1   3 , Teus van Laar  3   4 , Gea Drost  1   4
Affiliations

Supine MDS-UPDRS-III Assessment: An Explorative Study

Naomi I Kremer et al. J Clin Med. .

Abstract

The Movement Disorder Society Unified Parkinson's Disease Rating Scale-part III (MDS-UPDRS-III) is designed to be applied in the sitting position. However, to evaluate the clinical effect during stereotactic neurosurgery or to assess bedridden patients with Parkinson's disease (PD), the MDS-UPDRS-III is often used in a supine position. This explorative study evaluates the agreement of the MDS-UPDRS-III in the sitting and the supine positions. In 23 PD patients, the MDS-UPDRS-III was applied in both positions while accelerometric measurements were performed. Video recordings of the assessments were evaluated by two certified raters. Agreement between the sitting and supine MDS-UPDRS-III was studied using Cohen's kappa coefficient. Relationships between the MDS-UPDRS-III tremor scores and accelerometric amplitudes were calculated for both positions with linear regression. A fair to substantial agreement was found for MDS-UPDRS-III scores of individual items in the sitting and supine positions, while combining all tests resulted in a substantial agreement. The inter-rater reliability was fair to moderate for both positions. A logarithmic relationship between tremor scores and accelerometric amplitude was revealed for both the sitting and supine positions. Nevertheless, these data are insufficient to fully support the supine application of the MDS-UPDRS-III. Several recommendations are made to address the sensitivity of the scale to inter-rater variability. In conclusion, although an overall substantial agreement between sitting and supine MDS-UPDRS-III is confirmed, its application in the supine position is not endorsed for the whole range of its individual items. Caution is warranted in interpreting the supine MDS-UPDRS-III, pending additional research.

Keywords: MDS-UPDRS; accelerometry; motor section; supine; validation.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Cohen’s kappa for sitting and supine MDS-UDPRS-III scores. L: Left side. R: Right side. LUE: Left upper extremities. RUE: Right upper extremities. LLE: Left lower extremities. RLE: Right lower extremities.
Figure 2
Figure 2
Boxplots of the tremor amplitude of the sitting postural (a), supine postural (b), sitting rest (c), and supine rest (d) tremor tests (per MDS-UPDRS score).
See this image and copyright information in PMC

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