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. 2023 Oct;396(10):2519-2528.
doi: 10.1007/s00210-023-02472-y. Epub 2023 May 13.

Orientin regulates the proliferation and migration of hepatocellular carcinoma cells

Jia-Yi Tao #  1 , Jing Li #  2 , Lu Wan  3   4 , Bi-Zhen Dong  4 , Yong-Jie Yu  4 , Ye-Mao Liu  4 , Mao-Lin Yi  5 , Li-Peng Wan  6
Affiliations

Orientin regulates the proliferation and migration of hepatocellular carcinoma cells

Jia-Yi Tao et al. Naunyn Schmiedebergs Arch Pharmacol. 2023 Oct.

Abstract

Orientin is a flavone isolated from medicinal plants used in traditional Chinese medicine (TCM) that suppresses the growth of cancer cells in vitro. The effects of orientin in hepatoma carcinoma cells remain unknown. The aim of this paper is to investigate the effects of orientin on the viability, proliferation, and migration of hepatocellular carcinoma cells in vitro. In this study, we found that orientin could inhibit the proliferation, migration, and the activation of NF-κB signaling pathway in hepatocellular carcinoma cells. An activator of NF-κB signaling pathway, PMA, could abolish the inhibitory effect of orientin on NF-κB signaling pathway and proliferation and migration of Huh7 cells. These findings raise the possibility that orientin can be used in the treatment of hepatocellular carcinoma.

Keywords: HCC; HepG2; Huh7; NF-κB; Orientin.

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