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Comment
. 2023 May 12;4(5):288-289.
doi: 10.1016/j.medj.2023.04.005.

Unexpected worsening of doxorubicin cardiotoxicity upon intermittent fasting

Yiming Meng  1 , Jing Sun  2 , Guirong Zhang  3 , Tao Yu  4 , Haozhe Piao  5
Affiliations
Free article
Comment

Unexpected worsening of doxorubicin cardiotoxicity upon intermittent fasting

Yiming Meng et al. Med. .
Free article

Abstract

Recently in Cell Metabolism, Ozcan et al. used preclinical and clinical data to suggest that alternate-day fasting may exacerbate the cardiotoxic effects of doxorubicin through the TFEB/GDF15 pathway, leading to myocardial atrophy and impaired cardiac function. The link between caloric intake, chemotherapy-induced cachexia, and cardiotoxicity warrants more clinical attention.

Keywords: alternate-day fasting; cardiotoxicity; doxorubicin; intermittent fasting.

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Conflict of interest statement

Author contributions G.Z. and J.S. collected related articles. Y.M. designed and wrote the manuscript. Y.M., T.Y., and H.P. contributed to the critical revision of the English language. Y.M. was responsible for its financial support. All authors approved the final manuscript. Declaration of interests There are no conflicts of interest.

Comment on

  • Sustained alternate-day fasting potentiates doxorubicin cardiotoxicity.
    Ozcan M, Guo Z, Valenzuela Ripoll C, Diab A, Picataggi A, Rawnsley D, Lotfinaghsh A, Bergom C, Szymanski J, Hwang D, Asnani A, Kosiborod M, Zheng J, Hayashi RJ, Woodard PK, Kovacs A, Margulies KB, Schilling J, Razani B, Diwan A, Javaheri A. Ozcan M, et al. Cell Metab. 2023 Jun 6;35(6):928-942.e4. doi: 10.1016/j.cmet.2023.02.006. Epub 2023 Mar 2. Cell Metab. 2023. PMID: 36868222 Free PMC article. Clinical Trial.

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