Ammonia - an enduring foe - What evaluating whole body ammonia metabolism can teach us about cirrhosis and therapies treating hepatic encephalopathy

Affiliations

¹ Institute of Liver Studies, School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, 125 Coldharbour Lane, London, SE5 9NU, UK; Institute of Liver Studies, King's College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS, UK. Electronic address: debbie.shawcross@kcl.ac.uk.
² Brain Liver Pitié-Salpêtrière Study Group, Sorbonne Université, INSERM UMR_S 938, Centre de Recherche Saint-Antoine & Institute of Cardiometabolism and Nutrition (ICAN), AP-HP, Paris 75013, France; Sorbonne Université, Liver Intensive Care Unit, Hepatogastroenterology Department, Pitié-Salpêtrière Hospital, 47-83 Boulevard de l'Hôpital, Paris, 75013, France; Sorbonne Université, Paris, F-75005, France.
³ Senior Scholar, Department of Medicine, University of Padova, Italy.

Editorial

Debbie L Shawcross et al. J Hepatol. 2023 Aug.

. 2023 Aug;79(2):266-268.

doi: 10.1016/j.jhep.2023.04.039. Epub 2023 May 12.

¹ Institute of Liver Studies, School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, 125 Coldharbour Lane, London, SE5 9NU, UK; Institute of Liver Studies, King's College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS, UK. Electronic address: debbie.shawcross@kcl.ac.uk.
² Brain Liver Pitié-Salpêtrière Study Group, Sorbonne Université, INSERM UMR_S 938, Centre de Recherche Saint-Antoine & Institute of Cardiometabolism and Nutrition (ICAN), AP-HP, Paris 75013, France; Sorbonne Université, Liver Intensive Care Unit, Hepatogastroenterology Department, Pitié-Salpêtrière Hospital, 47-83 Boulevard de l'Hôpital, Paris, 75013, France; Sorbonne Université, Paris, F-75005, France.
³ Senior Scholar, Department of Medicine, University of Padova, Italy.

No abstract available

Keywords: Ammonia; Cirrhosis; Glycerol Phenylbutyrate; Lactulose; Portosystemic shunting; Rifaximin.

Comment on

Clearance and production of ammonia quantified in humans by constant ammonia infusion - the effects of cirrhosis and ammonia-targeting treatments.
Eriksen PL, Djernes L, Vilstrup H, Ott P. Eriksen PL, et al. J Hepatol. 2023 Aug;79(2):340-348. doi: 10.1016/j.jhep.2023.03.042. Epub 2023 Apr 13. J Hepatol. 2023. PMID: 37061198 Clinical Trial.