Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 May 2;3(1):e87.
doi: 10.1017/ash.2023.163. eCollection 2023.

Methicillin-resistant Staphylococcus aureus bacteremia with elevated vancomycin minimum inhibitory concentrations

Alexandra G Mills  1 , Amy C Dupper  1 , Kieran I Chacko  2 , Bremy Alburquerque  2 , Devika Nadkarni  1 , Ana Berbel Caban  1 , Lindsey Fox  1 , Melissa R Gitman  3 , Ajay Obla  2 , Harm van Bakel  2   4   5 , Deena R Altman  1   2
Affiliations

Methicillin-resistant Staphylococcus aureus bacteremia with elevated vancomycin minimum inhibitory concentrations

Alexandra G Mills et al. Antimicrob Steward Healthc Epidemiol. .

Abstract

This case-control study of 25 cases with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia with vancomycin minimum inhibitory concentration (MIC) ≥ 2 µg/mL and 391 controls (MIC < 2 µg/mL) characterized the clinical characteristics, treatments, and outcomes associated with elevated vancomycin MIC. Elevated vancomycin MIC was associated with baseline hemodialysis, prior MRSA colonization, and metastatic infection.

PubMed Disclaimer

Conflict of interest statement

Dr. Altman has received institutional funding from participation in ContraFect corporation clinical trials. The other authors have no financial or other conflicts of interest to disclose.

References

    1. Liu C, Bayer A, Cosgrove SE, Daum RS. Clinical practice guidelines by the Infectious Diseases Society of America for the treatment of methicillin-resistant Staphylococcus aureus Infections in Adults and children: executive summary. Clin Infect Dis 2011;52:285–292. - PubMed
    1. Mwangi MM, Wu SW, Zhou Y, et al. Tracking the in vivo evolution of multidrug resistance in Staphylococcus aureus by whole-genome sequencing. Proc Natl Acad Sci U S A 2007;104:9451–9456. - PMC - PubMed
    1. Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing. 31st Ed. CLSI Supplement m100. Malvern, PA: CLSI; 2021. - PMC - PubMed
    1. Chen SY, Hsueh PR, Chiang WC, et al. Predicting high vancomycin minimum inhibitory concentration isolate infection among patients with community-onset methicillin-resistant Staphylococcus aureus bacteraemia. J Infect 2014;69:259–265. - PubMed
    1. Liu C, Strnad L, Beekmann SE, Polgreen PM, Chambers HF. Clinical practice variation among adult infectious disease physicians in the management of Staphylococcus aureus bacteremia. Clin Infect Dis 2019;69:530–533. - PMC - PubMed

LinkOut - more resources