Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jan-Mar;38(1):69-70.
doi: 10.4103/ijnm.ijnm_134_22. Epub 2023 Feb 24.

Imaging Acute Myocarditis with 68Ga-DOTANOC PET/CT

Affiliations

Imaging Acute Myocarditis with 68Ga-DOTANOC PET/CT

Jasim Jaleel et al. Indian J Nucl Med. 2023 Jan-Mar.

Abstract

Somatostatin receptor (SSTR) imaging is a useful method in the diagnosis of acute myocarditis. We present a case of a 54-year-old male with a clinical diagnosis of acute myocarditis in whom, 68Ga-DOTANOC positron emission tomography/computed tomography PET/CT showed diffuse left ventricular myocardial uptake. SSTR imaging can act as a surrogate marker of active inflammation. SSTR imaging is useful in deciding site of biopsy, assessing response to therapy and for prognostication.

Keywords: DOTANOC; myocarditis; positron emission tomography/computed tomography; somatostatin receptor.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Axial CT (a), PET (b), and fused PET/CT (c) images showed diffuse heterogeneously increased tracer uptake in the entire left ventricular myocardium. Conventional slices of short axis (left panel), vertical long axis (middle panel), and horizontal long axis (right panel) showed a small perfusion defect in distal inferior wall on 99mTc-MIBI perfusion study (d1) and diffuse radiotracer uptake in the left ventricular myocardium on 68Ga-DOTANOC PET (d2). PET: Positron emission tomography, CT: Computed tomography

References

    1. Ten Bokum AM, Lichtenauer-Kaligis EG, Melief MJ, van Koetsveld PM, Bruns C, van Hagen PM, et al. Somatostatin receptor subtype expression in cells of the rat immune system during adjuvant arthritis. J Endocrinol. 1999;161:167–75. - PubMed
    1. Baghel V, Kaushik P, Seth S, Patel C. Somatostatin analogue scintigraphy in myocardial inflammation: An interesting image. J Nucl Cardiol. 2020;27:2436–7. - PubMed
    1. Amini A, Dehdar F, Jafari E, Gholamrezanezhad A, Assadi M. Somatostatin receptor scintigraphy in a patient with myocarditis. Mol Imaging Radionucl Ther. 2021;30:50–3. - PMC - PubMed
    1. Lapa C, Reiter T, Li X, Werner RA, Samnick S, Jahns R, et al. Imaging of myocardial inflammation with somatostatin receptor based PET/CT – A comparison to cardiac MRI. Int J Cardiol. 2015;194:44–9. - PubMed
    1. Spiridonidis T, Patsouras N, Papandrianos N, Symeonidis A, Apostolopoulos DJ. Tc-99m depreotide SPECT/CT depicts myocardial involvement in a case of thrombotic thrombocytopenic purpura. Clin Nucl Med. 2008;33:874–5. - PubMed