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Editorial
. 2023 Apr 28;12(4):701-704.
doi: 10.21037/tcr-23-192. Epub 2023 Apr 4.

Combining immunotherapy and radiotherapy in hepatocellular carcinoma: the importance of irradiated tumor burden and the possible role of a low dose radiotherapy induction strategy

Affiliations
Editorial

Combining immunotherapy and radiotherapy in hepatocellular carcinoma: the importance of irradiated tumor burden and the possible role of a low dose radiotherapy induction strategy

Clemens Grassberger et al. Transl Cancer Res. .
No abstract available

Keywords: Hepatocellular carcinoma (HCC); checkpoint inhibition; combination therapy; radiotherapy (RT); tumor burden.

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tcr.amegroups.com/article/view/10.21037/tcr-23-192/coif). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Tumor control probability (full lines, right axis) and surviving fraction of initial tumor burden (dashed lines, left axis) for a very radioresistant patient (red) and one of average radioresistance (blue). Prescribed dose based on a 5-fraction regimen with varying per fraction dose, no re-population was assumed during the 5-fraction treatment.

Comment on

References

    1. Juloori A, Katipally RR, Lemons JM, et al. Phase 1 Randomized Trial of Stereotactic Body Radiation Therapy Followed by Nivolumab plus Ipilimumab or Nivolumab Alone in Advanced/Unresectable Hepatocellular Carcinoma. Int J Radiat Oncol Biol Phys 2023;115:202-13. 10.1016/j.ijrobp.2022.09.052 - DOI - PubMed
    1. El-Khoueiry AB, Sangro B, Yau T, et al. Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial. Lancet 2017;389:2492-502. 10.1016/S0140-6736(17)31046-2 - DOI - PMC - PubMed
    1. Mushti SL, Mulkey F, Sridhara R. Evaluation of Overall Response Rate and Progression-Free Survival as Potential Surrogate Endpoints for Overall Survival in Immunotherapy Trials. Clin Cancer Res 2018;24:2268-75. 10.1158/1078-0432.CCR-17-1902 - DOI - PubMed
    1. Kim N, Cheng J, Huang WY, et al. Dose-Response Relationship in Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma: A Pooled Analysis of an Asian Liver Radiation Therapy Group Study. Int J Radiat Oncol Biol Phys 2021;109:464-73. 10.1016/j.ijrobp.2020.09.038 - DOI - PubMed
    1. Huang AC, Postow MA, Orlowski RJ, et al. T-cell invigoration to tumour burden ratio associated with anti-PD-1 response. Nature 2017;545:60-5. 10.1038/nature22079 - DOI - PMC - PubMed