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. 2023 Apr 27:10:1109910.
doi: 10.3389/fmed.2023.1109910. eCollection 2023.

Relationship between human serum albumin and in-hospital mortality in critical care patients with chronic obstructive pulmonary disease

Ma Ling  1 , Li Huiyin  2 , Chen Shanglin  3 , Li Haiming  1 , Di Zhanyi  1 , Wang Shuchun  1 , Bai Meng  4 , Lu Murong  2
Affiliations

Relationship between human serum albumin and in-hospital mortality in critical care patients with chronic obstructive pulmonary disease

Ma Ling et al. Front Med (Lausanne). .

Abstract

Background: The relationship between human serum albumin levels and the prognosis of critical care patients with chronic obstructive pulmonary disease (COPD) remains controversial.

Objective: To investigate the relationship between serum albumin levels and in-hospital mortality in critical care patients with COPD. METHODS: This study used a retrospective observational cohort from the Medical Information in Intensive Care database (MIMIC-IV) in the United States. Multivariate Cox regression analysis was used to assess the relationship between serum albumin levels and in-hospital mortality. A restricted cubic spline line was also used to explore nonlinear relationship.

Results: A total of 3,398 critical care patients with COPD were included. The overall in-hospital mortality was 12.4%. We found a negative relationship between human serum albumin and in-hospital mortality (HR = 0.97, 95% CI 0.96-0.99, p = 0.002).

Conclusion: In critical care patients with COPD, there was a negative association between human serum albumin and in-hospital mortality.

Keywords: ICU - intensive care unit; in-hospital mortality; relationship; serum albumin; severe chronic obstructive pulmonary disease.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Nonlinear relationship between serum albumin and in-hospital mortality (adjusted all covariates in Table 1).
Figure 2
Figure 2
Survival curves in the low albumin and high albumin groups.
Figure 3
Figure 3
Stratified analysis of relationship between serum albumin and in-hospital mortality. Adjusted for all cofounders in Table 1.
See this image and copyright information in PMC

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