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Review
. 2023 Mar 27:58:101886.
doi: 10.1016/j.eclinm.2023.101886. eCollection 2023 Apr.

MASCC clinical practice guidelines for the prevention and management of acute radiation dermatitis: part 1) systematic review

Tara Behroozian  1 , Daniel Goldshtein  2 , Julie Ryan Wolf  3 , Corina van den Hurk  4 , Samuel Finkelstein  5 , Henry Lam  6 , Partha Patel  7 , Lauren Kanee  8 , Shing Fung Lee  9   10 , Adrian Wai Chan  10 , Henry Chun Yip Wong  11 , Saverio Caini  12 , Simran Mahal  13 , Samantha Kennedy  13 , Edward Chow  14 , Pierluigi Bonomo  15 ; Multinational Association of Supportive Care in Cancer (MASCC) Oncodermatology Study Group Radiation Dermatitis Guidelines Working Group
Collaborators, Affiliations
Review

MASCC clinical practice guidelines for the prevention and management of acute radiation dermatitis: part 1) systematic review

Tara Behroozian et al. EClinicalMedicine. .

Abstract

Acute radiation dermatitis (ARD) commonly develops in cancer patients undergoing radiotherapy and is often characterized by erythema, desquamation, and pain. A systematic review was conducted to summarize the current evidence on interventions for the prevention and management of ARD. Databases were searched from 1946 to September 2020 to identify all original studies that evaluated an intervention for the prevention or management of ARD, with an updated search conducted in January 2023. A total of 235 original studies were included in this review, including 149 randomized controlled trials (RCTs). Most interventions could not be recommended due to a low quality of evidence, lack of supporting evidence, or conflicting findings across multiple trials. Photobiomodulation therapy, Mepitel® film, mometasone furoate, betamethasone, olive oil, and oral enzyme mixtures showed promising results across multiple RCTs. Recommendations could not be made solely based on the published evidence due to limited high-quality evidence. As such, Delphi consensus recommendations will be reported in a separate publication.

Keywords: Clinical practice guidelines; Management; Prevention; Radiation dermatitis; Radiotherapy; Skin toxicity; Systematic review.

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Conflict of interest statement

Julie Ryan Wolf declares BARDA funding for clinical trial for safety of Silverlon dressing for radiation dermatitis and UpToDate coauthor royalties. Tara Behroozian received a travel grant from the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group (Fall 2022). Edward Chow conducted a clinical trial and received materials free of cost from Mölnlycke Health Care. All other authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Literature search results from 1946 to September 2020.
See this image and copyright information in PMC

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