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. 2023 Apr 27:11:1100227.
doi: 10.3389/fpubh.2023.1100227. eCollection 2023.

Design, methodology, and baseline of eastern China student health and wellbeing cohort study

Xiyan Zhang  1   2 , Genming Zhao  3 , Jun Ma  4 , Fangbiao Tao  5 , Chen-Wei Pan  6 , Fengyun Zhang  1 , Yan Wang  1 , Wenyi Yang  1 , Yao Xiang  1 , Xin Wang  1 , Yunfan Tian  7 , Jie Yang  1   2 , Wei Du  8 , Yonglin Zhou  1 ; ES-SCI Work Group
Affiliations

Design, methodology, and baseline of eastern China student health and wellbeing cohort study

Xiyan Zhang et al. Front Public Health. .

Abstract

Purpose: To describe the study design, methodology, and cohort profile of the Eastern China Student Health and Wellbeing Cohort Study. The cohort baseline includes (1) targeted disease (myopia, obesity, elevated blood pressure, and mental health) and (2) exposures (individual behaviors, environment, metabolomics, and gene and epigenetics).

Participants: Annual physical examination, questionnaire-based survey, and bio-sampling have been carried out in the study population. In the first stage (2019-2021), a total of 6,506 students in primary schools are enrolled in the cohort study.

Findings to date: Of all the cohort participants, the ratio of male to female is 1.16 among a total of 6,506 student participants, of which 2,728 (41.9%) students are from developed regions and 3,778 (58.1%) students are from developing regions. The initial age of observation is 6-10 years, and they will be observed until they graduate from high school (>18 years of age). (1) Targeted diseases: The growth rates of myopia, obesity, and high blood pressure vary by regions, and for developed regions, the prevalence of myopia, obesity, and elevated blood pressure is 29.2%, 17.4%, and 12.6% in the first year, respectively. For developing regions, the prevalence of myopia, obesity, and elevated blood pressure is 22.3%, 20.7%, and 17.1% in the first year, respectively. The average score of CES-D is 12.9 ± 9.8 in developing regions/11.6 ± 9.0 in developed regions. (2) Exposures: ① The first aspect of individual behaviors: the questionnaire topics include diet, physical exercise, bullying, and family. ② The second aspect of environment and metabolomics: the average desk illumination is 430.78 (355.84-611.56) LX, and the average blackboard illumination is 365.33 (286.83-516.84) LX. Metabolomics like bisphenol A in the urine is 0.734 ng/ml. ③ The third aspect of gene and epigenetics: SNPs (rs524952, rs524952, rs2969180, rs2908972, rs10880855, rs1939008, rs9928731, rs72621438, rs9939609, rs8050136 and so on) are detected.

Future plans: Eastern China Student Health and Wellbeing Cohort Study is aiming to focus on the development of student-targeted diseases. For children with student common diseases, this study will focus on targeted disease-related indicators. For children without targeted disease, this study aims to explore the longitudinal relationship between exposure factors and outcomes, excluding baseline confounding factors. Exposure factors include three aspects: (1) individual behaviors, (2) environment and metabolomics, and (3) gene and epigenetics. The cohort study will continue until 2035.

Keywords: cohort; health; profile; school aged; wellbeing.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Map of China and the location of the Eastern China Student Health and Wellbeing Cohort Study, including Pei county, Yizheng city, Changshu city, and Dongtai city.
Figure 2
Figure 2
The flowchart of the organization, management, and implementation in the ES-SCI Study (Eastern Chinese Students common disease Surveillance, Cohort, and Intervention study).
See this image and copyright information in PMC

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