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Case Reports
. 2023 Apr 10;15(4):e37401.
doi: 10.7759/cureus.37401. eCollection 2023 Apr.

Skin Metastasis of Low-Grade Ovarian Serous Carcinoma: A Case Report

Lauren M Ching  1 , Benjamin A Tran  2 , Kristen L Russomanno  2 , Michael A Cardis  3
Affiliations
Case Reports

Skin Metastasis of Low-Grade Ovarian Serous Carcinoma: A Case Report

Lauren M Ching et al. Cureus. .

Abstract

This case report, written with the assistance of ChatGPT, describes a rare manifestation of ovarian serous carcinoma that metastasized to the skin. A 30-year-old female with a history of stage IV low-grade serous ovarian carcinoma presented for evaluation of a painful nodule on her back. Physical examination demonstrated a round, firm, mobile subcutaneous nodule on the left upper back. An excisional biopsy was performed, and histopathologic examination was consistent with metastatic ovarian serous carcinoma. This case highlights the clinical presentation, histopathology, and treatment of cutaneous metastasis of serous ovarian carcinoma. Additionally, this case highlights the value and technique of using ChatGPT to assist in writing medical case reports including outlining, referencing, summarizing studies, and formatting citations.

Keywords: chatgpt; cutaneous metastasis; low-grade serous carcinoma; ovarian carcinoma; serous carcinoma.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. H&E 20x magnification. Lobular collections of pleomorphic epithelial cells demonstrating glandular differentiation and embedded in a fibromucinous stroma with scattered necrotic cells and mitotic figures.
Figure 2
Figure 2. H&E 40x magnification. Higher power magnification.
Figure 3
Figure 3. ChatGPT's construction of a patient case presentation.
A. Our entry to ChatGPT as we gave it raw notes from the patient chart (de-identified) to use in its construction. B. ChatGPT crafted a succinct presentation in paragraph format.
Figure 4
Figure 4. ChatGPT extensions.
This figure shows our use of two ChatGPT extensions in writing the case discussion. A. Our entry using the WebChatGPT extension allows ChatGPT to extract the latest data on the internet to use in the responses. A list of 10 references is generated for us via the extension. We simply requested the following: “Using recently published scholarly articles, write me a discussion on low grade ovarian serous carcinoma”. B. ChatGPT's response to our WebChatGPT entry C. Our use of the ChatGPT Summary extension. This extension allows you to highlight any text on the internet such as in other references, and it will summarize the key points found in the text.
Figure 5
Figure 5. Reference formatting using ChatGPT.
A. Our entry into ChatGPT requesting our references to be formatted in AMA format B. ChatGPT's response
See this image and copyright information in PMC

References

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    1. Cutaneous metastases in ovarian cancer. Otsuka I. Cancers (Basel) 2019;11 - PMC - PubMed
    1. Skin metastases in epithelial ovarian and fallopian tube carcinoma. Otsuka I, Matsuura T. Medicine (Baltimore) 2017;96:0. - PMC - PubMed
    1. Metastatic tumors of the skin. Brownstein MH, Helwig EB. Cancer. 1972;29:1298–1307. - PubMed
    1. The proliferation markers Ki-67/MIB-1, phosphohistone H3, and survivin may contribute in the identification of aggressive ovarian carcinomas. Aune G, Stunes AK, Tingulstad S, Salvesen Ø, Syversen U, Torp SH. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127066/ Int J Clin Exp Pathol. 2011;4:444–453. - PMC - PubMed

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