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Case Reports
. 2023 Apr 10;15(4):e37365.
doi: 10.7759/cureus.37365. eCollection 2023 Apr.

Invasive Breast Carcinoma With Sebaceous Morphologic Pattern Showing Lymph Node Macrometastasis: A Case Report

Juan Carlos Alvarez Moreno  1 , Jing He  1
Affiliations
Case Reports

Invasive Breast Carcinoma With Sebaceous Morphologic Pattern Showing Lymph Node Macrometastasis: A Case Report

Juan Carlos Alvarez Moreno et al. Cureus. .

Abstract

Invasive ductal carcinoma of no special type can present with various patterns. It is not possible to diagnose them through imaging alone. Microscopic examination is necessary to accurately identify and characterize them. The sebaceous pattern was historically considered a distinct subtype of breast carcinoma. However, the number of cases is relatively small and the prognosis has not been fully established. In this paper, we present a case of invasive ductal carcinoma with focal sebaceous features, which had a macrometastasis to the axillary lymph nodes showing the sebaceous morphology.

Keywords: breast cancer; invasive ductal carcinoma; metastasis; sebaceous carcinoma; sebaceous pattern.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. A: The gross examination showed a firm white mass lesion with infiltrative borders (arrow). B: The histologic examination of this mass lesion revealed solid growth of nests of tumor cells with abundant vacuolated cytoplasm and eccentrically located scalloped nuclei, which suggested sebaceous differentiation (magnification: 20×). C: Microscopic examination of the sebaceous pattern of breast carcinoma that metastasized to the axillary lymph node (magnification: 20×). D1-D2: Immunohistochemistry showing the tumor cells in the lymph node were positive for AE1/AE3 and expressed estrogen receptor (magnification: 20×).
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