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Review
. 2023 Aug:74:102379.
doi: 10.1016/j.pbi.2023.102379. Epub 2023 May 12.

Integration of discovery and engineering in plant alkaloid research: Recent developments in elucidation, reconstruction, and repurposing biosynthetic pathways

Van-Hung Bui  1 , Carlos Eduardo Rodríguez-López  2 , Thu-Thuy T Dang  3
Affiliations
Review

Integration of discovery and engineering in plant alkaloid research: Recent developments in elucidation, reconstruction, and repurposing biosynthetic pathways

Van-Hung Bui et al. Curr Opin Plant Biol. 2023 Aug.

Abstract

Plants synthesize tens of thousands of bioactive nitrogen-containing compounds called alkaloids, including some clinically important drugs in modern medicine. The discovery of new alkaloid structures and their metabolism in plants have provided ways to access these rich sources of bioactivities including new-to-nature compounds relevant to therapeutic and industrial applications. This review discusses recent advances in alkaloid biosynthesis discovery, including complete pathway elucidations. Additionally, the latest developments in the production of new and established plant alkaloids based on either biosynthesis or semisynthesis are discussed.

Keywords: Alkaloids; Biosynthesis; New-in-nature; New-to-nature; Semisynthesis.

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Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships that may be considered as potential competing interests: Thu-Thuy Thi Dang reports financial support was provided by Natural Sciences and Engineering Research Council of Canada. Thu-Thuy T. Dang reports financial support was provided by Michael Smith Foundation for Health Research. Carlos Eduardo Rodriguez Lopez reports financial support was provided by the Tecnologico de Monterrey.

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