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Review
. 2023 Jul;238(7):1416-1430.
doi: 10.1002/jcp.31031. Epub 2023 May 14.

Sarcopenia and noncoding RNAs: A comprehensive review

Soudeh Ghafouri-Fard  1 , Arian Askari  2 , Bashdar Mahmud Hussen  3 , Mohammad Taheri  4 , Arda Kiani  5
Affiliations
Review

Sarcopenia and noncoding RNAs: A comprehensive review

Soudeh Ghafouri-Fard et al. J Cell Physiol. 2023 Jul.

Abstract

Sarcopenia is an elderly disease and is related to frailty and loss of muscle mass (atrophy) of older adults. The exact molecular mechanisms contributing to the pathogenesis of disease are yet to be discovered. In recent years, the role of noncoding RNAs in the pathogenesis of almost every kind of malignant and nonmalignant conditions is pinpointed. Regarding their regulatory function, there have been an increased number of studies on the role of noncoding RNAs in the progress of sarcopenia. In this manuscript, we review the role of microRNAs and long noncoding RNAs in development and progression of disease. We also discuss their potential as therapeutic targets in this condition.

Keywords: lncRNA; miRNAs; muscle atrophy; noncoding RNA; sarcopenia.

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References

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