10th antibody industrial symposium: new developments in antibody and adoptive cell therapies
- PMID: 37184206
- PMCID: PMC10187075
- DOI: 10.1080/19420862.2023.2211692
10th antibody industrial symposium: new developments in antibody and adoptive cell therapies
Abstract
The annual "Antibody Industrial Symposium", co-organized by LabEx MAbImprove and MabDesign, held its 10th anniversary edition in Montpellier, France, on June 28-29, 2022. The meeting focused on new results and concepts in antibody engineering (naked, mono- or multi-specific, conjugated to drugs or radioelements) and also on new cell-based therapies, such as chimeric antigenic receptor (CAR)-T cells. The symposium, which brought together scientists from academia and industry, also addressed issues concerning the production of these molecules and cells, and the necessary steps to ensure a strong intellectual property protection of these new molecules and approaches. These two days of exchanges allowed a rich discussion among the various actors in the field of therapeutic antibodies.
Keywords: Antibody engineering; Antibody industrial symposium; Intellectual property; antibody-related molecules; biotherapeutics; cell-based therapies; congress; research translation into clinic; therapeutic antibodies.
Conflict of interest statement
No potential conflict of interest was reported by the authors.
References
-
- Parthiban K, Perera RL, Sattar M, Huang Y, Mayle S, Masters E, Griffiths D, Surade S, Leah R, Dyson MR, et al. A comprehensive search of functional sequence space using large mammalian display libraries created by gene editing. MAbs. 2019;11(5):884–12. PMID:31107136. doi:10.1080/19420862.2019.1618673. - DOI - PMC - PubMed
-
- Dyson MR, Masters E, Pazeraitis D, Perera RL, Syrjanen JL, Surade S, Thorsteinson N, Parthiban K, Jones PC, Sattar M, et al. Beyond affinity: selection of antibody variants with optimal biophysical properties and reduced immunogenicity from mammalian display libraries. MAbs. 2020;12(1):1829335. PMID:33103593. doi:10.1080/19420862.2020.1829335. - DOI - PMC - PubMed
-
- Leick MB, Silva H, Scarfò I, Larson R, Choi BD, Bouffard AA, Gallagher K, Schmidts A, Bailey SR, Kann MC, et al. Non-cleavable hinge enhances avidity and expansion of CAR-T cells for acute myeloid leukemia. Cancer Cell. 2022;40(5):494–508.e5. PMID:35452603. doi:10.1016/j.ccell.2022.04.001. - DOI - PMC - PubMed
-
- Haradhvala NJ, Leick MB, Maurer K, Gohil SH, Larson RC, Yao N, Gallagher KME, Katsis K, Frigault MJ, Southard J, et al. Distinct cellular dynamics associated with response to CAR-T therapy for refractory B cell lymphoma. Nat Med. 2022;28(9):1848–59. PMID:36097221. doi:10.1038/s41591-022-01959-0. - DOI - PMC - PubMed
-
- Jin H, D’Urso V, Neuteboom B, McKenna SD, Schweickhardt R, Gross AW, Fomekong Nanfack Y, Paoletti A, Carter C, Toleikis L, et al. Avelumab internalization by human circulating immune cells is mediated by both Fc gamma receptor and PD-L1 binding. OncoImmunology. 2021;10(1):1958590. PMID:34484871. doi:10.1080/2162402X.2021.1958590. - DOI - PMC - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources