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Comment
. 2023 Jul 3;220(7):e20230550.
doi: 10.1084/jem.20230550. Epub 2023 May 15.

Guardians of the oral barriers

Affiliations
Comment

Guardians of the oral barriers

Marcus Buggert. J Exp Med. .

Abstract

The oral mucosa serves as a frontline defense against many infections. Stolley et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20221853) discovered that the oral mucosa houses CD8+ CD103+ resident memory T cells, which are important for protecting against local viral infections in mice.

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Insights from Marcus Buggert.
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Induction of oral CD103+ TRMs promotes a localized pro-inflammatory response and provides protection against viral disease. ISG, interferon-stimulated gene.

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References

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