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. 2023 Jul 26;29(42):e202300603.
doi: 10.1002/chem.202300603. Epub 2023 Jun 16.

Micelle-Mediated Sonogashira Coupling for DNA-Encoded Library Synthesis

Jessica S Graham  1 , Harriet A Stanway-Gordon  1 , Michael J Waring  1
Affiliations

Micelle-Mediated Sonogashira Coupling for DNA-Encoded Library Synthesis

Jessica S Graham et al. Chemistry. .

Abstract

DNA-Encoded Libraries (DELs) are becoming widely established as a hit identification strategy for drug discovery campaigns. Their successful application relies on the availability and efficiency of the reactions that can be carried out on DNA. These reactions should proceed with high conversion to the desired product and have a broad substrate scope to synthesise chemically diverse and drug-like DELs. The Sonogashira coupling provides a unique means of coupling an sp-hybridized carbon centre to an aryl halide and methods to achieve this reaction on DNA are highly desirable. We report the application of our micellar technology for on-DNA chemistry to the Sonogashira reaction. This method gives highly efficient conversions for the coupling of (hetero)aromatic and aliphatic alkynes to (hetero)aryl iodides and bromides allowing the preparation of highly diverse DELs.

Keywords: DNA encoded libraries; Sonogashira; cross-coupling; micellar catalysis.

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