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. 2023 Apr 20;30(4):4289-4300.
doi: 10.3390/curroncol30040327.

Clinicopathological Characteristics, Treatment Patterns, and Outcomes in Patients with Laryngeal Cancer

Dejan Đokanović  1   2 , Radoslav Gajanin  2 , Zdenka Gojković  1   2 , Goran Marošević  2   3 , Igor Sladojević  2 , Vesna Gajanin  2 , Olja Jović-Đokanović  2   4 , Ljiljana Amidžić  2
Affiliations

Clinicopathological Characteristics, Treatment Patterns, and Outcomes in Patients with Laryngeal Cancer

Dejan Đokanović et al. Curr Oncol. .

Abstract

Background: Various factors can affect the survival of patients with laryngeal cancer (LC). In this retrospective study, we assessed clinicopathological features, their prognostic value, and treatment modalities for patients with confirmed squamous cell LC.

Methods: We collected patient data on demographics, clinicopathological characteristics, treatment patterns, and outcomes. The primary endpoints were overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), and locoregional control (LRC). We assessed survival using the Kaplan-Meier method and Cox regression model analyses of potential prognostic parameters.

Results: After a median follow-up of 76 months, 28 (33.3%) patients had a recurrence. The median OS was 78 months, with an event recorded in 50% of patients. The DSS median was not reached (NR) with a survival rate of 72.6%, the DFS survival rate was 66.7% with median NR, and the LRC survival rate was 72.6% with median NR. After conducting a multivariate analysis of significant variables, we found that only recurrence and lymphatic invasion had an independent effect on OS and recurrence in DSS, while subsite impacted DFS and LRC.

Conclusions: Survival trends were consistent with other studies, except for OS. Recurrence, lymphatic invasion, and subsite location were significant factors that impacted patient survival.

Keywords: laryngeal cancer; prognosis; recurrence; survival.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of patient selection.
Figure 2
Figure 2
(a) Kaplan–Meier curve showing OS, median 78 months; (b) DSS, median NR; (c) DFS, median NR; (d) LRC, median NR.
Figure 3
Figure 3
Kaplan–Meier curve showing OS in different treatment groups, log-rank p = 0.009.
See this image and copyright information in PMC

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