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. 2023 Apr 20;30(4):4351-4364.
doi: 10.3390/curroncol30040331.

A Systematic Review Assessing the Impact of Vitamin D Levels on Adult Patients with Lymphoid Malignancies

Cristina Potre  1 , Ema Borsi  1 , Ovidiu Potre  1 , Ioana Ionita  1 , Miruna Samfireag  2 , Dan Costachescu  3 , Cristina Secosan  4 , Sandra Lazar  5 , Anca Irina Ristescu  6   7
Affiliations

A Systematic Review Assessing the Impact of Vitamin D Levels on Adult Patients with Lymphoid Malignancies

Cristina Potre et al. Curr Oncol. .

Abstract

Vitamin D deficiency has been correlated with various conditions, including the risk of developing lymphoid malignancies. This systematic review aimed to assess the association between vitamin D levels at diagnosis of lymphoid malignancies, patient outcomes, and survival. A systematic review was conducted, encompassing 15 studies published until January 2023, involving 4503 patients, examining the relationship between vitamin D and lymphoid cancers. The median age of the patients was 56.5 years, with a median follow-up duration of approximately 36 months across studies. The overall median vitamin D level at initial measurement was 20.4 ng/mL, while a <20 ng/mL threshold was used to define vitamin D insufficiency. The results demonstrated significant associations between vitamin D levels and patient outcomes in several lymphoid malignancies, with a pooled risk in disease progression of 1.93 and a pooled hazard ratio of 2.06 for overall survival in patients with 25-(OH)D levels below the normal threshold of 20 ng/mL. Among findings, it was demonstrated that supplemental vitamin D improves the chemosensitivity of tumors by reducing the rate of tumor growth compared with vitamin D or chemotherapy alone. Vitamin D had a protective effect for patients with DLBCL under R-CHOP treatment, while vitamin D insufficiency was associated with the impairment of rituximab treatment and showed worse clinical outcomes in chimeric antigen receptor T-cell (CAR-T) recipients. Although one study found no association between vitamin D deficiency and the cause of death, most associated vitamin D insufficiency with early clinical failure and lower survival probability. In conclusion, his systematic review highlights the importance of vitamin D levels in the prognosis and survival of patients with lymphoid malignancies. Further research is needed to better understand the underlying mechanisms and explore the potential benefits of vitamin D supplementation in managing these cancers.

Keywords: hematologic malignancy; lymphoid tissue; substance addiction; survival analysis; vitamin D.

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Conflict of interest statement

The authors declare no conflict of interest.

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PRISMA flow diagram.
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References

    1. Postlethwaite A.E., Tuckey R.C., Kim T.K., Li W., Bhattacharya S.K., Myers L.K., Brand D.D., Slominski A.T. 20S-Hydroxyvitamin D3, a Secosteroid Produced in Humans, Is Anti-Inflammatory and Inhibits Murine Autoimmune Arthritis. Front. Immunol. 2021;12:678487. doi: 10.3389/fimmu.2021.678487. - DOI - PMC - PubMed
    1. Cesari M., Incalzi R.A., Zamboni V., Pahor M. Vitamin D hormone: A multitude of actions potentially influencing the physical function decline in older persons. Geriatr. Gerontol. Int. 2011;11:133–142. doi: 10.1111/j.1447-0594.2010.00668.x. - DOI - PMC - PubMed
    1. Vanderschueren D., Pye S.R., O’Neill T.W., Lee D.M., Jans I., Billen J., Gielen E., Laurent M., Claessens F., Adams J.E., et al. Active vitamin D (1,25-dihydroxy vitamin D) and bone health in middle-aged and elderly men: The European Male Aging Study (EMAS) J. Clin. Endocrinol. Metab. 2013;98:995–1005. doi: 10.1210/jc.2012-2772. - DOI - PubMed
    1. Pike J.W., Meyer M.B. The vitamin D receptor: New paradigms for the regulation of gene expression by 1,25-dihydroxyvitamin D(3) Endocrinol. Metab. Clin. N. Am. 2010;39:255–269. doi: 10.1016/j.ecl.2010.02.007. - DOI - PMC - PubMed
    1. Krishnan A.V., Trump D.L., Johnson C.S., Feldman D. The role of vitamin D in cancer prevention and treatment. Endocrinol. Metab. Clin. N. Am. 2010;39:401–418. doi: 10.1016/j.ecl.2010.02.011. - DOI - PMC - PubMed

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