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. 2023 Jan-Jun;17(1):34-40.
doi: 10.4103/ajts.ajts_103_21. Epub 2022 Sep 28.

Feasibility of high-yield plateletpheresis in routine practice: Experience from tertiary health center from South India

Dibyajyoti Sahoo  1 , Shahida Noushad  1 , Abhishekh Basavarajegowda  1 , Esha Toora  1
Affiliations

Feasibility of high-yield plateletpheresis in routine practice: Experience from tertiary health center from South India

Dibyajyoti Sahoo et al. Asian J Transfus Sci. 2023 Jan-Jun.

Abstract

Background and objectives: High-yield plateletpheresis donations can reduce donor exposure and be economically beneficial as well. However, obtaining a high-yield plateletpheresis from a maximum number of donors with low basal platelet count and its effect on postdonation platelet count of donors undergoing high-yield plateletpheresis has been a matter of concern. This study aimed to assess the feasibility of making high-yield platelet donation as a routine practice.

Methods: It was a retrospective observational study to determine the effect of high-yield plateletpheresis on donor reactions, efficacy, and quality parameters. It was conducted from January 1, 2019 to June 30, 2021, at the Department of Transfusion Medicine in a tertiary care hospital of South India.

Results: Out of the 669 procedures, 564 (84.3%) of the collection had a platelet yield of ≥5 × 1011, 468 (70%) of the collection had a platelet yield of 5.5 × 1011, whereas 284 (42.5%) met the target of 6 × 1011 by coulter. The mean drops in platelet count were 95 ± 16 × 103/μl (77,600-113,000/μl), mean platelet recruitment was 1.31 ± 0.51. The mean collection efficiency of the procedure for the 669 cases was shown to be 80.21 ± 15.34, and the mean collection rate was 0.07 × 1011 ± 0.02 per minute. Only forty donors (5.5%) experienced adverse donor reactions.

Conclusions: High-yield plateletpheresis can be done in routine practice with no added adverse donor reaction with effective quality products.

Keywords: Donor reactions; Trima Accel; high-yield plateletpheresis; platelet yield.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
The observed adverse reactions during high-yield plateletpheresis
See this image and copyright information in PMC

References

    1. Sahoo D, Mahapatra S, Parida P, Panigrahi R. Various aspects of plateletpheresis: Its impact on donor and patients. Glob J Transfus Med. 2017;2:149–54.
    1. Kumawat V, Goyal M, Marimuthu P. Analysis of donor safety in high yield plateletpheresis procedures: An experience from tertiary care hospital in South India. Indian J Hematol Blood Transfus. 2020;36:542–9. - PMC - PubMed
    1. Klumpp TR, Herman JH, Gaughan JP, Russo RR, Christman RA, Goldberg SL, et al. Clinical consequences of alterations in platelet transfusion dose: A prospective, randomized, double-blind trial. Transfusion. 1999;39:674–81. - PubMed
    1. Makroo RN, Fadadu D, Agrawal S, Chowdhry M. Double dose plateletpheresis: A savior to shrinking donor pool and platelet inventory management. Indian J Hematol Blood Transfus. 2018;34:691–6. - PMC - PubMed
    1. Chaudhary R, Das SS, Khetan D, Ojha S, Verma S. Donor safety issues in high-dose platelet collection using the latest apheresis systems. Transfus Altern Transfus Med. 2010;11:1–7.