Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 May-Jun:888:503635.
doi: 10.1016/j.mrgentox.2023.503635. Epub 2023 Apr 3.

Aneugenic and clastogenic alterations in the DBA/IJ mouse model of rheumatoid arthritis treated with rituximab, an anti-CD20 antibody

Sabry M Attia  1 , Mohammed A Al-Hamamah  2 , Moureq R Alotaibi  2 , Abdullah F Alasmari  2 , Mohamed S M Attia  2 , Sheikh F Ahmad  2 , Mohamed A Mahmoud  2 , Ahmed Nadeem  2 , Mushtaq A Ansari  2 , Saleh A Bakheet  2
Affiliations

Aneugenic and clastogenic alterations in the DBA/IJ mouse model of rheumatoid arthritis treated with rituximab, an anti-CD20 antibody

Sabry M Attia et al. Mutat Res Genet Toxicol Environ Mutagen. 2023 May-Jun.

Abstract

Rheumatoid arthritis (RA), an autoimmune disorder in which the immune system attacks healthy cells, is associated with elevated risk of lymphoma. Rituximab, a treatment for non-Hodgkin's lymphoma, has been approved as a treatment for RA. We studied the effects of rituximab on chromosomal stability in collagen-induced arthritis DBA/1J animal models. Micronucleus levels were increased in the mouse models, mainly due to chromosome loss, as detected by fluorescence in situ hybridization; rituximab-treated arthritic mice had significantly less micronucleus formation. Serum 8-hydroxydeoxyguanosine, a DNA oxidative stress marker, was increased in the mice models but reduced following rituximab administration.

Keywords: 8-OHdG; Aneugenicity; Anti-CD20; Clastogenicity; Inflammation; Oxidative DNA damage.

PubMed Disclaimer

Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

LinkOut - more resources