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. 2023 Apr 10;13(8):1377.
doi: 10.3390/diagnostics13081377.

Retinal Nerve Fiber Layer Imaging with Two Different Spectral Domain Optical Coherence Tomographs: Normative Data for Romanian Children

Iulia-Andrada Nemeș-Drăgan  1   2 , Ana-Maria Drăgan  3 , Mădălina Claudia Hapca  4 , Mara Oaida  5
Affiliations

Retinal Nerve Fiber Layer Imaging with Two Different Spectral Domain Optical Coherence Tomographs: Normative Data for Romanian Children

Iulia-Andrada Nemeș-Drăgan et al. Diagnostics (Basel). .

Abstract

The purpose of this study is to analyze and compare pediatric normative data for the retinal nerve fiber layer of Romanian children using two different spectral domain optical coherence tomographs. Due to different scanning speeds and axial and transverse resolution, the results of the measurements of scans cannot be transposed. A total of 140 healthy children aged 4 to 18 were enrolled in the study. Overall, 140 eyes were scanned with a Spectralis SD-OCT (Heidelberg Technology), and the other 140 eyes were imaged with a Copernicus REVO SOCT (Optopol Technology (Zawiercie, Poland)). The mean global RNFL thickness and average RNFL thickness for the four quadrants were measured and compared. The average peripapillary RNFL thickness measured with the Spectralis was 104.03 ± 11.42 (range 81 to 126 µm), while the one measured with the Revo 80 was 127.05 ± 15.6 (range 111.43-158.28). The RNFL thickness measurements taken with the Spectralis in the superior, inferior, nasal, and temporal quadrants were 132 ±19.1, 133.5 ± 21.77, 74 ± 16.48, and 73 ± 11.95 µm, respectively, while those taken with the Revo 80 were 144.44 ± 9.25, 144.86 ±23.12, 96.49 ± 19.41, and 77 ± 11.4 µm, respectively. Multivariate analysis showed that the average RNFL thickness was not influenced by gender or eye laterality and was negatively correlated with age when we used the Spectralis device. This study provides normative data for SD-OCT peripapillary RNFL in healthy Romanian children for two different tomographs. These data help the clinician evaluate and interpret the results of optical coherence tomography for a child, taking into consideration all the technical and individual parameters.

Keywords: RNFL thickness; Romanian children; normative data; spectral domain OCT.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
(a) Spectralis SD-OCT scans of retinal nerve fiber layer thickness map. (b) SOCT Copernicus REVO NFL thickness profile. [Personal database].
Figure 2
Figure 2
Clustered bar chart displaying the differences between mean values of global and sectorial RNFL in Spectralis and Revo80.
Figure 3
Figure 3
Bland–Altman chart of Spectralis and Revo80 measurements for Global RNFL, where ◦ is difference, -- mean, and -- lower and upper 95% limit values.
Figure 4
Figure 4
Scatterplot of global RNFL (A) and superior sector RNFL (B) thickness as a function of age of the subjects on Spectralis measurements.
See this image and copyright information in PMC

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