Sulphate transport in human placental brush-border membrane vesicles: competitive inhibition by selenate

Abstract

The effect of selenate on sulphate uptake by human placental brush-border membrane vesicles has been investigated. Selenate added to the incubation medium inhibits 1 mM sulphate uptake in a dose-dependent fashion with a Ki of approx. 2.5 mM. The inhibition by selenate is competitive, suggesting that selenate and sulphate share a common transporter (an anion exchange system) which may be of particular importance for the transport of such essential trace elements to the fetus.