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. 2023 Apr 7;10(4):694.
doi: 10.3390/children10040694.

Description of Copy Number Variations in a Series of Children and Adolescents with FASD in Reunion Island

Laëtitia Sennsfelder  1   2 , Susie Guilly  2 , Sébastien Leruste  3   4 , Ludovic Hoareau  2 , Willy Léocadie  2 , Pauline Beuvain  2 , Meïssa Nekaa  5 , Maïté Bagard  5 , Stéphanie Robin  6 , Justine Lanneaux  6 , Léa Etchebarren  6 , Marilyn Tallot  6 , Michel Spodenkiewicz  3   7 , Jean-Luc Alessandri  2   8 , Godelieve Morel  2   8 , Maud Blanluet  2 , Paul Gueguen  2 , Bérénice Roy-Doray  1   2   3   5   8
Affiliations

Description of Copy Number Variations in a Series of Children and Adolescents with FASD in Reunion Island

Laëtitia Sennsfelder et al. Children (Basel). .

Abstract

Background: Fetal Alcohol Spectrum Disorders (FASD) are the most common cause of neurocognitive impairment and social inadaptation, affecting 1 birth in 100. Despite the existence of precise diagnostic criteria, the diagnosis remains difficult, often confounded with other genetic syndromes or neurodevelopmental disorders. Since 2016, Reunion Island has been a pilot region for the identification, diagnosis, and care of FASD in France.

Objective: To evaluate the prevalence and the types of Copy Number Variations (CNV) in FASD patients.

Methods: A retrospective chart review of 101 patients diagnosed with FASD in the Reference Center for developmental anomalies and in the FASD Diagnostic Center of the University Hospital was performed. Records of all patients were reviewed to obtain their medical history, family history, clinical phenotype, and investigations, including genetic testing (CGH- or SNP-array).

Results: A rate of 20.8% (n = 21) of CNVs was found including 57% (12/21) of pathogenic variants and 29% (6/21) of variants of uncertain signification (VUS).

Conclusion: A particularly high number of CNVs was found in children and adolescents with FASD. It reinforces the plea for a multidisciplinary approach for developmental disorders to explore both environmental factors, such as avoidable teratogens and intrinsic vulnerabilities, especially genetic determinants.

Keywords: chromosomal analysis on DNA chip; copy number variation; fetal alcohol spectrum disorder.

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Conflict of interest statement

The authors declare no conflict of interest.

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