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Editorial
. 2023 Jul 14;29(14):2563-2566.
doi: 10.1158/1078-0432.CCR-23-0652.

An Attempt to Stretch the Benefit: Rechallenge with PARP Inhibitors in Ovarian Cancer

Eduardo Gonzalez-Ochoa  1 , Amit M Oza  1   2
Affiliations
Editorial

An Attempt to Stretch the Benefit: Rechallenge with PARP Inhibitors in Ovarian Cancer

Eduardo Gonzalez-Ochoa et al. Clin Cancer Res. .

Abstract

PARP inhibitors exploit synthetic lethality in homologous recombination-deficient (HDR) cells and are standard-of-care treatment in newly diagnosed and relapsed epithelial ovarian cancer (EOC). A recent article demonstrated that a second course of olaparib can be safely administered to women with BRCA-mutated EOC. See related article by Morgan et al., p. 2602.

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