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Review
. 2022 Jan 19;1(1):100004.
doi: 10.1016/j.cellin.2022.100004. eCollection 2022 Feb.

Long non-coding RNA and non-coding nucleic acids: Signaling players in the networks of the tumor ecosystem

Xiaorong Lin  1   2 , Man-Li Luo  3   4 , Erwei Song  3   5
Affiliations
Review

Long non-coding RNA and non-coding nucleic acids: Signaling players in the networks of the tumor ecosystem

Xiaorong Lin et al. Cell Insight. .

Erratum in

Abstract

Recent findings have revealed that human genome encodes tens of thousands long noncoding RNAs (lncRNAs), which play essential roles in broad spectrum of cellular processes. Emerging evidence has uncovered a new archetype of lncRNAs which functions as key components of cell signaling pathways. In this review, we describe how lncRNAs interact with proteins to regulate cancer intracellular signaling and intercellular signaling in the tumor microenvironment (TME), which enable cancer cells to acquire malignant hallmarks. Moreover, besides lncRNAs, non-coding nucleic acids, such as neutrophil extracellular trap-DNA (NET-DNA), endogenous DNA and RNA, can act as signal molecules to connect cells from distant organs and trigger systemic responses in the macroenvironment of tumor-bearing hosts. Overall, the widely observed dysregulation of non-coding nucleic acids in cancer alters signaling networks in the tumor ecosystem, providing a rich resource for the identification of cancer biomarkers and therapeutic targets.

Keywords: Long non-coding RNA; Non-coding nucleic acid; Signaling transduction; Tumor ecosystem.

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Figures

Fig. 1
Fig. 1
LncRNAs in cancer signaling transduction. LncRNAs bind to protein partners and regulate their post-translational modifications or interactions with other proteins, which play important roles in signaling transduction in cancer pathways.
See this image and copyright information in PMC

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