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. 2023 May 13;6(2):ooad035.
doi: 10.1093/jamiaopen/ooad035. eCollection 2023 Jul.

A global federated real-world data and analytics platform for research

Matvey B Palchuk  1   2 , Jack W London  3 , David Perez-Rey  4 , Zuzanna J Drebert  1 , Jessamine P Winer-Jones  1 , Courtney N Thompson  1 , John Esposito  1 , Brecht Claerhout  1
Affiliations

A global federated real-world data and analytics platform for research

Matvey B Palchuk et al. JAMIA Open. .

Abstract

Objective: This article describes a scalable, performant, sustainable global network of electronic health record data for biomedical and clinical research.

Materials and methods: TriNetX has created a technology platform characterized by a conservative security and governance model that facilitates collaboration and cooperation between industry participants, such as pharmaceutical companies and contract research organizations, and academic and community-based healthcare organizations (HCOs). HCOs participate on the network in return for access to a suite of analytics capabilities, large networks of de-identified data, and more sponsored trial opportunities. Industry participants provide the financial resources to support, expand, and improve the technology platform in return for access to network data, which provides increased efficiencies in clinical trial design and deployment.

Results: TriNetX is a growing global network, expanding from 55 HCOs and 7 countries in 2017 to over 220 HCOs and 30 countries in 2022. Over 19 000 sponsored clinical trial opportunities have been initiated through the TriNetX network. There have been over 350 peer-reviewed scientific publications based on the network's data.

Conclusions: The continued growth of the TriNetX network and its yield of clinical trial collaborations and published studies indicates that this academic-industry structure is a safe, proven, sustainable path for building and maintaining research-centric data networks.

Keywords: clinical trial protocols; data management; data warehouse; electronic health records; real-world data.

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Conflict of interest statement

MBP, ZJD, JPW-J, CNT, JE, and BC are employees of TriNetX, LLC. JWL and DP-R have a Consulting Role with TriNetX, LLC.

Figures

Figure 1.
Figure 1.
HCO members of TriNetX and a sample of various networks they comprise. For each network, the number of HCOs and patients is shown. Circle sizes are approximate. EMEA: Europe, Middle East and Africa.
Figure 2.
Figure 2.
Map of HCOs currently under contract. Microsoft Bing Maps screenshot reprinted with permission from Microsoft Corporation.
Figure 3.
Figure 3.
Growth of data on the TriNetX platform between 2019 and 2022. Counts for 2020 are omitted.
Figure 4.
Figure 4.
Cumulative requests to HCOs from pharmaceutical companies and contract research organizations for participation in clinical trials. The bar graph shows the cumulative number of requests, broken down by geographic regions, and the orange line—unique opportunities available to HCOs.
Figure 5.
Figure 5.
Number of conference abstracts and peer-reviewed journal articles from studies utilizing TriNetX. The counts for 2022 are partial and cover publications from January to September.
See this image and copyright information in PMC

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