Nordic 2023 guidelines for the diagnosis and treatment of lung neuroendocrine neoplasms

Gitte Dam¹, Henning Grønbæk¹, Anna Sundlöv², Johan Botling³, Anders Sundin⁴, Rene Horsleben Petersen^{5

6}, Staffan Welin⁷, Espen-Thiis Evensen⁸, Halfdan Sorbye⁹, Elizaveta Tabaksblat¹⁰, Anne Kirstine Arveschoug¹¹, Jann Mortensen¹², Andreas Kjaer¹², Ulrich Knigge¹³, Eva Tiensuu Janson⁷, Seppo W Langer¹⁴

Affiliations

¹ Department of Hepatology & Gastroenterology, ENETS Center of Excellence, Aarhus University Hospital, & Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
² Division of Oncology, Department of Clinical Sciences Lund, Lund University, Sweden.
³ Department of Immunology Genetics and Pathology, ENETS Center of Excellence, Uppsala University, Uppsala, Sweden.
⁴ Department of Surgical Sciences, Radiology & Molecular Imaging, ENETS Center of Excellence, Uppsala University, Uppsala, Sweden.
⁵ Department of Cardiothoracic Surgery, ENETS Center of Excellence, Copenhagen University Hospital, Rigshospitalet, Denmark.
⁶ Department of Clinical Medicine, University of Copenhagen, Denmark.
⁷ Department of Medical Sciences, Endocrine Oncology Unit, ENETS Center of Excellence, Uppsala University, Uppsala, Sweden.
⁸ Department for Organ Transplantation, Oslo University Hospital, ENETS Center of Excellence, Rikshospitalet, Oslo, Norway.
⁹ Department of Oncology, Haukeland University Hospital, and Department of Clinical Science, University of Bergen, Bergen, Norway.
¹⁰ Department of Oncology, ENETS Center of Excellence, Aarhus University Hospital, Aarhus, Denmark.
¹¹ Department of Nuclear Medicine & PET Center, Aarhus University Hospital, ENETS Center of Excellence, Aarhus, Denmark.
¹² Department. of Clinical Physiology and Nuclear Medicine, ENETS Center of Excellence & Cluster for Molecular Imaging, Copenhagen University Hospital-Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Denmark.
¹³ Departments of Gastrointestinal Surgery and Clinical Endocrinology, ENETS Center of Excellence, Copenhagen University Hospital, Rigshospitalet, Denmark.
¹⁴ Department of Oncology, ENETS Center of Excellence, Copenhagen University Hospital, Rigshospitalet, and Dept. of Clinical Medicine, University of Copenhagen, Denmark.

PMID: 37194281
DOI: 10.1080/0284186X.2023.2212411

Review

Nordic 2023 guidelines for the diagnosis and treatment of lung neuroendocrine neoplasms

Gitte Dam et al. Acta Oncol. 2023 May.

. 2023 May;62(5):431-437.

doi: 10.1080/0284186X.2023.2212411. Epub 2023 May 16.

Authors

Affiliations

¹ Department of Hepatology & Gastroenterology, ENETS Center of Excellence, Aarhus University Hospital, & Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
² Division of Oncology, Department of Clinical Sciences Lund, Lund University, Sweden.
³ Department of Immunology Genetics and Pathology, ENETS Center of Excellence, Uppsala University, Uppsala, Sweden.
⁴ Department of Surgical Sciences, Radiology & Molecular Imaging, ENETS Center of Excellence, Uppsala University, Uppsala, Sweden.
⁵ Department of Cardiothoracic Surgery, ENETS Center of Excellence, Copenhagen University Hospital, Rigshospitalet, Denmark.
⁶ Department of Clinical Medicine, University of Copenhagen, Denmark.
⁷ Department of Medical Sciences, Endocrine Oncology Unit, ENETS Center of Excellence, Uppsala University, Uppsala, Sweden.
⁸ Department for Organ Transplantation, Oslo University Hospital, ENETS Center of Excellence, Rikshospitalet, Oslo, Norway.
⁹ Department of Oncology, Haukeland University Hospital, and Department of Clinical Science, University of Bergen, Bergen, Norway.
¹⁰ Department of Oncology, ENETS Center of Excellence, Aarhus University Hospital, Aarhus, Denmark.
¹¹ Department of Nuclear Medicine & PET Center, Aarhus University Hospital, ENETS Center of Excellence, Aarhus, Denmark.
¹² Department. of Clinical Physiology and Nuclear Medicine, ENETS Center of Excellence & Cluster for Molecular Imaging, Copenhagen University Hospital-Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Denmark.
¹³ Departments of Gastrointestinal Surgery and Clinical Endocrinology, ENETS Center of Excellence, Copenhagen University Hospital, Rigshospitalet, Denmark.
¹⁴ Department of Oncology, ENETS Center of Excellence, Copenhagen University Hospital, Rigshospitalet, and Dept. of Clinical Medicine, University of Copenhagen, Denmark.

PMID: 37194281
DOI: 10.1080/0284186X.2023.2212411

Abstract

Lung neuroendocrine neoplasms (NEN) are a heterogeneous population of neoplasms with different pathology, clinical behavior, and prognosis compared to the more common lung cancers. The diagnostic work-up and treatment of patients with lung- NEN has undergone major recent advances and new methods are currently being introduced into the clinic. These Nordic guidelines summarize and update the Nordic Neuroendocrine Tumor Group's current view on how to diagnose and treat lung NEN-patients and are meant to be useful in the daily practice for clinicians handling these patients. This review reflects our view of the current state of the art of diagnosis and treatment of patients with lung-NEN. Small cell lung carcinoma (SCLC) is not included in these guidelines.

Keywords: Lung; bronchopulmonary neoplasm; diagnosis; neuroendocrine carcinoma; neuroendocrine neoplasm; treatment.

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Nordic 2023 guidelines for the diagnosis and treatment of lung neuroendocrine neoplasms

Affiliations

Nordic 2023 guidelines for the diagnosis and treatment of lung neuroendocrine neoplasms

Authors

Affiliations

Abstract

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical