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. 2023 Aug;70(8):e30424.
doi: 10.1002/pbc.30424. Epub 2023 May 17.

A retrospective review on the histopathological pattern of childhood malignant solid tumors in Ethiopia

Rahell Hailu Ayele  1 , Yodit Getahun Yimer  1 , Yonas Bekuretsion  1 , Lulu M Muhe  1 , Shivani A Patel  2 , Solveig A Cunningham  2 , Daniel Hailu  1 , Benjamin Watkins  3
Affiliations

A retrospective review on the histopathological pattern of childhood malignant solid tumors in Ethiopia

Rahell Hailu Ayele et al. Pediatr Blood Cancer. 2023 Aug.

Abstract

In low- and middle-income countries (LMICs), malignancies remain underreported due to lack of quality data. This study outlines the histopathological pattern of pediatric solid malignancies in children aged 0-15 years at the largest referral hospital in Ethiopia. A total of 432 solid malignancies were evaluated. The most common malignancies were lymphoma (21.8%), retinoblastoma (19.4%), and Wilms tumor (13.9%). Burkitt lymphoma accounted for 2.1%, despite being the most reported pediatric malignancy in sub-Saharan Africa in published literature. Definitive diagnosis could not be made in 7% of cases, related to the lack of confirmatory testing. The study highlights the need for improvement in diagnostic capabilities in LMICs.

Keywords: Ethiopia; childhood cancers; solid tumors.

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