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. 2023 Aug;45(8):e2300046.
doi: 10.1002/bies.202300046. Epub 2023 May 17.

BENDing with Polycomb in pluripotency and cancer

Abid Khan  1 , Supriya Prasanth  2   3
Affiliations

BENDing with Polycomb in pluripotency and cancer

Abid Khan et al. Bioessays. 2023 Aug.

Abstract

Three recent publications on BEND3 firmly establish its role as a novel sequence-specific transcription factor that is essential for PRC2 recruitment and maintenance of pluripotency. Here, we briefly review our current understanding of the BEND3-PRC2 axis in the regulation of pluripotency and also explore the possibility of a similar connection in cancer.

Keywords: BEND3; EZH2; PRC2; pluripotency; stem cells.

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Conflict of interest statement

The authors declare no competing financial interests.

Figures

Figure 1:
Figure 1:
BEND3 and EZH2 correlation in cancer. A, BEND3 mRNA expression levels in Normal and Tumor samples of the indicated cancers on x-axis. y-axis is normalized counts. Graph was generated on UALCAN (University of Alabama Cancer data analysis) Portal. B, Scatter plot of BEND3 expression on x-axis and EZH2 expression on y-axis, plotted on cBioPortal using TCGA Pan-Cancer dataset. C, Scatter plot of CEBPB expression on x-axis and EZH2 expression on y-axis, plotted on cBioPortal using TCGA Pan-Cancer dataset. D, Scatter plot of MTF2 expression on x-axis and EZH2 expression on y-axis, plotted on cBioPortal using TCGA Pan-Cancer dataset. E, Scatter plot of BEND3 expression on x-axis and EZH2 expression on y-axis in breast carcinoma (BRCA) dataset obtained from TCGA. F, Scatter plot of BEND3 expression on x-axis and EZH2 expression on y-axis in glioblastoma multiforme (GBM) dataset obtained from TCGA. Data were downloaded from cBioPortal and graphs were generated using Prism9 software.
See this image and copyright information in PMC

References

    1. Sathyan KM et al. (2011) A BEN-domain-containing protein associates with heterochromatin and represses transcription. J Cell Sci 124, 3149–3163. 10.1242/jcs.086603 - DOI - PMC - PubMed
    1. Dai Q et al. (2013) The BEN domain is a novel sequence-specific DNA-binding domain conserved in neural transcriptional repressors. Genes Dev 27, 602–614. 10.1101/gad.213314.113 - DOI - PMC - PubMed
    1. Khan A et al. (2015) BEND3 represses rDNA transcription by stabilizing a NoRC component via USP21 deubiquitinase. Proc Natl Acad Sci U S A 112, 8338–8343. 10.1073/pnas.1424705112 - DOI - PMC - PubMed
    1. Kurniawan F et al. (2022) BEND3 safeguards pluripotency by repressing differentiation-associated genes. Proc Natl Acad Sci U S A 119. 10.1073/pnas.2107406119 - DOI - PMC - PubMed
    1. Zhang J et al. (2022) Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation. Science 375, 1053–1058. 10.1126/science.abm0730 - DOI - PubMed

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