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. 2024 May;37(3):475-478.
doi: 10.1007/s10548-023-00967-8. Epub 2023 May 17.

EEG Microstates as a Signature of Hemispheric Lateralization in Stroke

Maria Rubega  1 , Massimiliano Facca  2 , Vittorio Curci  3 , Giovanni Sparacino  3 , Franco Molteni  4 , Eleonora Guanziroli  4 , Stefano Masiero  1   2 , Emanuela Formaggio #  1   2 , Alessandra Del Felice #  5   6
Affiliations

EEG Microstates as a Signature of Hemispheric Lateralization in Stroke

Maria Rubega et al. Brain Topogr. 2024 May.

Abstract

Stroke recovery trajectories vary substantially. The need for tracking and prognostic biomarkers in stroke is utmost for prognostic and rehabilitative goals: electroencephalography (EEG) advanced signal analysis may provide useful tools toward this aim. EEG microstates quantify changes in configuration of neuronal generators of short-lasting periods of coordinated synchronized communication within large-scale brain networks: this feature is expected to be impaired in stroke. To characterize the spatio-temporal signatures of EEG microstates in stroke survivors in the acute/subacute phase, EEG microstate analysis was performed in 51 first-ever ischemic stroke survivors [(28-82) years, 24 with right hemisphere (RH) lesion] who underwent a resting-state EEG recording in the acute and subacute phase (from 48 h up to 42 days after the event). Microstates were characterized based on 4 parameters: global explained variance (GEV), mean duration, occurrences per second, and percentage of coverage. Wilcoxon Rank Sum tests were performed to compare features of each microstate across the two groups [i.e., left hemisphere (LH) and right hemisphere (RH) stroke survivors]. The canonical microstate map D, characterized by a mostly frontal topography, displayed greater GEV, occurrence per second, and percentage of coverage in LH than in RH stroke survivors (p < 0.05). The EEG microstate map B, with a left-frontal to right-posterior topography, and F, with an occipital-to-frontal topography, exhibited a greater GEV in RH than in LH stroke survivors (p = 0.015). EEG microstates identified specific topographic maps which characterize stroke survivors' lesioned hemisphere in the acute and early subacute phase. Microstate features offer an additional tool to identify different neural reorganization.

Keywords: EEG; Hemispheric lateralization; Microstates; Stroke.

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Conflict of interest statement

The authors declare they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Ordered and named microstate maps of the two groups (left and right hemisphere stroke). Topographies were ordered based on Custo et al. (2017)
Fig. 2
Fig. 2
Mean value of microstate features and associated p-values of the difference between LH and RH stroke for microstate classes B, D and F′ vs. F. Error bars indicate the standard deviation
See this image and copyright information in PMC

References

    1. Abreu R, Jorge J, Leal A, et al. EEG microstates predict concurrent fMRI dynamic functional connectivity states. Brain Topogr. 2021;34:41–55. doi: 10.1007/s10548-020-00805-1. - DOI - PubMed
    1. Bentes C, Peralta AR, Viana P, Martins H, Morgado C, Casimiro C, Franco AC, Fonseca AC, Geraldes R, Canhão P, Pinho E, Melo T, Paiva T, Ferro JM. Quantitative EEG and functional outcome following acute ischemic stroke. Clin Neurophysiol. 2018;129(8):1680–1687. doi: 10.1016/j.clinph.2018.05.021. - DOI - PubMed
    1. Custo A, Van De Ville D, Wells WM, Tomescu MI, Brunet D, Michel CM. Electroencephalographic resting-state networks: source localization of microstates. Brain Connect. 2017;7(10):671–682. doi: 10.1089/brain.2016.0476. - DOI - PMC - PubMed
    1. Donkor ES. Stroke in the 21st century: a snapshot of the burden, epidemiology, and quality of life. Stroke Res Treat. 2018 doi: 10.1155/2018/3238165. - DOI - PMC - PubMed
    1. Hao Z, Zhai X, Cheng D, Pan Y, Dou W. EEG microstate-specific functional connectivity and stroke-related alterations in brain dynamics. Front Neurosci. 2022 doi: 10.3389/fnins.2022.848737. - DOI - PMC - PubMed