Lynch syndrome-related colorectal carcinomas are NTRK-negative

Affiliations

¹ Department of Pathology, "Mater Salutis" Hospital, Verona (VR), Italy.
² Department of Surgical and Diagnostic Sciences (DISC), University of Genoa and S. Martino Polyclinic Hospital, Genoa (GE), Italy.
³ Anatomic Pathology Unit, Department of Molecular Medicine, University of Pavia and Fondazione IRCCS San Matteo Hospital, Pavia, Italy.
⁴ Unit of Pathology, Fondazione IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, FG, Italy.
⁵ Department of Medicine (DIMED), Surgical Pathology Unit, University of Padua, Padua (PD), Italy.
⁶ Chirurgia Generale 3^, Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, Padua, Italy.
⁷ Medical Oncology Unit 1, Clinical and Experimental Oncology Department, Veneto Institute of Oncology, IOV-IRCCS, Padua (PD), Italy.
⁸ Veneto Institute of Oncology, IOV-IRCCS, Padua (PD), Italy.

Andrea Remo et al. Histopathology. 2023 Aug.

. 2023 Aug;83(2):335-336.

doi: 10.1111/his.14944. Epub 2023 May 17.

¹ Department of Pathology, "Mater Salutis" Hospital, Verona (VR), Italy.
² Department of Surgical and Diagnostic Sciences (DISC), University of Genoa and S. Martino Polyclinic Hospital, Genoa (GE), Italy.
³ Anatomic Pathology Unit, Department of Molecular Medicine, University of Pavia and Fondazione IRCCS San Matteo Hospital, Pavia, Italy.
⁴ Unit of Pathology, Fondazione IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, FG, Italy.
⁵ Department of Medicine (DIMED), Surgical Pathology Unit, University of Padua, Padua (PD), Italy.
⁶ Chirurgia Generale 3^, Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, Padua, Italy.
⁷ Medical Oncology Unit 1, Clinical and Experimental Oncology Department, Veneto Institute of Oncology, IOV-IRCCS, Padua (PD), Italy.
⁸ Veneto Institute of Oncology, IOV-IRCCS, Padua (PD), Italy.

No abstract available

Keywords: BRAF; Lynch syndrome; MLH1 methylation; NTRK; colorectal carcinoma.

References

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1. Ukkola I, Nummela P, Kero M et al. Gene fusions and oncogenic mutations in MLH1 deficient and BRAFV600E wild-type colorectal cancers. Virchows Arch 2022; 480; 807-817.