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Randomized Controlled Trial
. 2023 Aug;31(8):2139-2149.
doi: 10.1002/oby.23808. Epub 2023 Jul 9.

Reducing BMI below the obesity threshold in adolescents treated with once-weekly subcutaneous semaglutide 2.4 mg

Aaron S Kelly  1 , Silva Arslanian  2 , Dan Hesse  3 , Aske Thorn Iversen  3 , Antje Körner  4   5 , Signe Schmidt  3 , Rasmus Sørrig  3 , Daniel Weghuber  6 , Ania M Jastreboff  7
Affiliations
Randomized Controlled Trial

Reducing BMI below the obesity threshold in adolescents treated with once-weekly subcutaneous semaglutide 2.4 mg

Aaron S Kelly et al. Obesity (Silver Spring). 2023 Aug.

Abstract

Objective: The aim of this study was to examine how improvement in BMI with the glucagon-like peptide-1 receptor agonist semaglutide translated to changes in BMI category in a post hoc analysis of the double-blind, phase 3a randomized controlled Semaglutide Treatment Effect in People with obesity (STEP) TEENS trial.

Methods: Adolescents with obesity received once-weekly subcutaneous semaglutide 2.4 mg or placebo plus lifestyle intervention, which comprised counseling in healthy nutrition and a goal of 60 minutes of moderate- to high-intensity physical activity per day. Achievement of an improvement in BMI category and attainment of normal-weight or overweight BMI by week 68 were analyzed using logistic regression models.

Results: In the overall population, 44.9% of participants receiving semaglutide achieved weight reduction resulting in reclassification to a normal-weight or overweight BMI category versus 12.1% receiving placebo at week 68 (odds ratio: 22.7; 95% CI: 7.6-67.9). The proportion of semaglutide-treated participants in obesity class III decreased from 37.3% to 13.6% but increased with placebo. The odds ratio for achieving an improvement of at least one BMI category was significantly greater with semaglutide versus placebo (23.5; 95% CI: 9.9-55.5); an improvement of at least one BMI category was seen in 73.7% of participants receiving semaglutide compared with 19.0% of participants receiving placebo.

Conclusions: Semaglutide was highly effective in reducing BMI category. While on treatment, most trial participants' BMI improved by at least one category, and >40% reached a category below the obesity threshold.

Trial registration: ClinicalTrials.gov NCT04102189.

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References

REFERENCES

    1. Hampl SE, Hassink SG, Skinner AC, et al. Clinical practice guideline for the evaluation and treatment of children and adolescents with obesity. Pediatrics. 2023;151(2):e2022060640. doi:10.1542/peds.2022-060640
    1. Moradi M, Mozaffari H, Askari M, Azadbakht L. Association between overweight/obesity with depression, anxiety, low self-esteem, and body dissatisfaction in children and adolescents: a systematic review and meta-analysis of observational studies. Crit Rev Food Sci Nutr. 2022;62(2):555-570. doi:10.1080/10408398.2020.1823813
    1. Freedman DS, Lawman HG, Galuska DA, Goodman AB, Berenson GS. Tracking and variability in childhood levels of BMI: the Bogalusa Heart Study. Obesity (Silver Spring). 2018;26(7):1197-1202. doi:10.1002/oby.22199
    1. Geserick M, Vogel M, Gausche R, et al. Acceleration of BMI in early childhood and risk of sustained obesity. N Engl J Med. 2018;379(14):1303-1312. doi:10.1056/NEJMoa1803527
    1. Simmonds M, Burch J, Llewellyn A, et al. The use of measures of obesity in childhood for predicting obesity and the development of obesity-related diseases in adulthood: a systematic review and meta-analysis. Health Technol Assess. 2015;19(43):1-336. doi:10.3310/hta19430

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