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Comment
. 2023 May 16;4(5):101046.
doi: 10.1016/j.xcrm.2023.101046.

Air pollution, EGFR mutation, and cancer initiation

Si-Chong Han  1 , Gui-Zhen Wang  1 , Guang-Biao Zhou  2
Affiliations
Comment

Air pollution, EGFR mutation, and cancer initiation

Si-Chong Han et al. Cell Rep Med. .

Abstract

Swanton et al.1 find that PM2.5 exposure is associated with EGFR/KRAS-driven lung cancer incidence. PM2.5 increases EGFR pre-mutated alveolar type II cell progenitor function and tumorigenic activity through interstitial macrophage-secreted IL-1β, providing potential prevention approaches to inhibit cancer initiation.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Figures

Figure 1
Figure 1
PM2.5 and EGFR mutation in promotion of lung cancer (A) Identification of the association between the estimated incidence of EGFR-driven lung cancer and PM2.5 exposure. (B) The mechanisms of PM2.5 in promoting EGFR-driven lung cancer. IL-1β mediates PM2.5-induced enhancement of a progenitor-like cell state of mutant EGFR-harboring ATII cells, and an anti-IL-1β antibody reduces lung cancer incidence in mice.
See this image and copyright information in PMC

Comment on

  • Lung adenocarcinoma promotion by air pollutants.
    Hill W, Lim EL, Weeden CE, Lee C, Augustine M, Chen K, Kuan FC, Marongiu F, Evans EJ Jr, Moore DA, Rodrigues FS, Pich O, Bakker B, Cha H, Myers R, van Maldegem F, Boumelha J, Veeriah S, Rowan A, Naceur-Lombardelli C, Karasaki T, Sivakumar M, De S, Caswell DR, Nagano A, Black JRM, Martínez-Ruiz C, Ryu MH, Huff RD, Li S, Favé MJ, Magness A, Suárez-Bonnet A, Priestnall SL, Lüchtenborg M, Lavelle K, Pethick J, Hardy S, McRonald FE, Lin MH, Troccoli CI, Ghosh M, Miller YE, Merrick DT, Keith RL, Al Bakir M, Bailey C, Hill MS, Saal LH, Chen Y, George AM, Abbosh C, Kanu N, Lee SH, McGranahan N, Berg CD, Sasieni P, Houlston R, Turnbull C, Lam S, Awadalla P, Grönroos E, Downward J, Jacks T, Carlsten C, Malanchi I, Hackshaw A, Litchfield K; TRACERx Consortium; DeGregori J, Jamal-Hanjani M, Swanton C. Hill W, et al. Nature. 2023 Apr;616(7955):159-167. doi: 10.1038/s41586-023-05874-3. Epub 2023 Apr 5. Nature. 2023. PMID: 37020004 Free PMC article.

References

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