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Editorial
. 2023 Sep;31(9):1154-1155.
doi: 10.1016/j.joca.2023.05.002. Epub 2023 May 16.

Towards disease modification in osteoarthritis

Francesco Dell'Accio  1 , Cosimo De Bari  2
Affiliations
Free article
Editorial

Towards disease modification in osteoarthritis

Francesco Dell'Accio et al. Osteoarthritis Cartilage. 2023 Sep.
Free article

Abstract

In December 2022, Gerwin et al published in Nature Medicine that the C-terminal portion of angiopoietin-like 3, called LNA043, has chondroprotective and cartilage-regenerative properties. Molecular data from an experimental medicine phase I study suggested potential efficacy in humans. Here, we respond to and complement a commentary from Vincent and Conaghan and discuss unresolved issues and the potential of this molecule as a disease-modifying osteoarthritis drug.

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Conflict of interest statement

Conflicts of interest F.D.A. has received consultancy fees from UCB and Biosplice Therapeutics. C.D.B. has received research grant funding through the institution from Biosplice Therapeutics, and consultancy fees from UCB, Galapagos, and Cellthrion Healthcare.

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