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Review
. 2023 Sep;22(3):453-456.
doi: 10.1007/s42000-023-00451-9. Epub 2023 May 17.

Hybrid closed-loop systems can help patients with extreme fear of hypoglycemia or hyperglycemia

Natalia Mangas  1 , Manel Mateu-Salat  1 , María José Martínez  1 , Alicia López  1 , Isabel Pujol  1 , Carmen Martínez  1 , Rosa Corcoy  2   3   4   5
Affiliations
Review

Hybrid closed-loop systems can help patients with extreme fear of hypoglycemia or hyperglycemia

Natalia Mangas et al. Hormones (Athens). 2023 Sep.

Abstract

Fear of hypoglycemia and hyperglycemia can lead to inappropriate diabetes self-management and untoward health outcomes. We report two patients, representative of these opposite conditions, who benefited from hybrid closed-loop technology. In the patient with fear of hypoglycemia, time in range improved from 26 to 56% and the patient did not present with severe hypoglycemia. Meanwhile, the patient with hyperglycemia aversiveness had a drastic reduction in time below range, from 19 to 4%. We conclude that hybrid closed-loop technology was an effective tool for improvement of glucose values in two patients with fear of hypoglycemia and hyperglycemia aversiveness, respectively.

Keywords: Fear of hypoglycemia; Hybrid closed-loop systems; Hyperglycemia aversiveness.

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References

    1. Zhang Y, Li S, Zou Y, Wu X, Bi Y, Zhang L et al (2020) Fear of hypoglycemia in patients with type 1 and 2 diabetes: a systematic review. J Clin Nurs 30(1–2):72–82
    1. Martyn-Nemeth P, Schwarz Farabi S, Mihailescu D, Nemeth J, Quinn L (2016) Fear of hypoglycemia in adults with type 1 diabetes: impact of therapeutic advances and strategies for prevention — a review. J Diabetes Complications 30(1):167–177 - DOI - PubMed
    1. Polonsky WH, Fortmann AL, Price D, Fisher L (2021) “Hyperglycemia aversiveness”: investigating an overlooked problem among adults with type 1 diabetes. J Diabetes Complications 35(6):107925 - DOI - PubMed
    1. Boughton CK, Hovorka R (2021) New closed-loop insulin systems. Diabetologia 64(5):1007–1015 - DOI - PubMed - PMC
    1. Nallicheri A, Mahoney KM, Gutow HA, Bellini N, Isaacs D (2022) Review of automated insulin delivery systems for type 1 diabetes and associated time in range outcomes. Touchrev Endocrinol 18(1):27–34 - DOI - PubMed - PMC

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