Treating infants with 0.2% propranolol eye micro-drops drastically reduced the progression of retinopathy of prematurity

Affiliations

¹ Neonatology Unit, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
² Department of Biology, University of Pisa, Pisa, Italy.
³ Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
⁴ Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.
⁵ Hospital Pharmacy, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
⁶ Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Rosa Teresa Scaramuzzo et al. Acta Paediatr. 2023 Sep.

. 2023 Sep;112(9):1905-1906.

doi: 10.1111/apa.16850. Epub 2023 May 24.

¹ Neonatology Unit, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
² Department of Biology, University of Pisa, Pisa, Italy.
³ Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
⁴ Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.
⁵ Hospital Pharmacy, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
⁶ Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

No abstract available

References

1. Filippi L et al. Decoupling oxygen tension from retinal vascularization as a new perspective for management of retinopathy of prematurity. New opportunities from β-aadrenoceptors. Front Pharmacol. 2022;13:835771.
1. Kong HB, Zheng GY, He BM, Zhang Y, Zhou Q. Clinical efficacy and safety of propranolol in the prevention and treatment of retinopathy of prematurity: a meta-analysis of randomized controlled trials. Front Pediatr. 2021;9:631673.
1. Filippi L, Cavallaro G, Bagnoli P, et al. Oral propranolol for retinopathy of prematurity: risks, safety concerns, and perspectives. J Pediatr. 2013;163:1570-1577.e6.
1. Filippi L, Cavallaro G, Berti E, et al. Propranolol 0.2% eye micro-drops for retinopathy of prematurity: a prospective phase IIB study. Front Pediatr. 2019;7:180.
1. Lucchesi M et al. Neurosensory alterations in retinopathy of prematurity: a window to neurological impairments associated to preterm birth. Biomedicine. 2022;10:1603.