Neocytolysis after return from high altitude (5100 m): Further evidence for absentia

Lars Kaestner^{1

2}, Benoit Champigneulle^{3

4}, Émeric Stauffer^{5

6

7}, Michael Furian³, Jérémy De Abreu³, Thomas John², Elie Nader^{5

6}, Anja Scheller⁸, Aurélien Pichon⁹, Philippe Connes^{5

6}, Paul Robach¹⁰, Julien V Brugniaux³, Christian Borsch¹¹, Silvia Rudloff¹¹, Heimo Mairbäurl¹², Samuel Verges³

Affiliations

¹ Theoretical Medicine and Biosciences, Campus University Hospital, Saarland University, Homburg, Germany.
² Experimental Physics, Saarland University, Saarbruecken, Germany.
³ University Grenoble Alpes, Inserm, CHU Grenoble Alpes, HP2, Grenoble, France.
⁴ Department of Anesthesia and Critical Care, Grenoble Alpes University Hospital, Grenoble, France.
⁵ Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM) EA7424, Team "Vascular Biology and Red Blood Cell", Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France.
⁶ Laboratoire d'Excellence du Globule Rouge (Labex GR-Ex), PRES Sorbonne, Paris, France.
⁷ Exploration Fonctionnelle Respiratoire, Médecine du Sport et de l'Activité Physique, Hospices Civils de Lyon, Hôpital Croix Rousse, Lyon, France.
⁸ Molecular Physiology, Center for Integrative Physiology and Molecular Medicine, Saarland University, Homburg, Germany.
⁹ University of Poitiers, MOVE Laboratory UR 20296, Faculté des Sciences du Sport, Poitiers, France.
¹⁰ National School for Mountain Sports, Site of the National School for Skiing and Mountaineering (ENSA), Chamonix, France.
¹¹ Analytical Platform, Stable Isotopes and Cell Biology, Institute of Nutritional Sciences, Justus Liebig University Giessen, Giessen, Germany.
¹² Translational Pneumology, University Hospital Heidelberg, Heidelberg, Germany.

Editorial

Lars Kaestner et al. Acta Physiol (Oxf). 2023 Jul.

. 2023 Jul;238(3):e14002.

doi: 10.1111/apha.14002. Epub 2023 Jun 8.

¹ Theoretical Medicine and Biosciences, Campus University Hospital, Saarland University, Homburg, Germany.
² Experimental Physics, Saarland University, Saarbruecken, Germany.
³ University Grenoble Alpes, Inserm, CHU Grenoble Alpes, HP2, Grenoble, France.
⁴ Department of Anesthesia and Critical Care, Grenoble Alpes University Hospital, Grenoble, France.
⁵ Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM) EA7424, Team "Vascular Biology and Red Blood Cell", Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France.
⁶ Laboratoire d'Excellence du Globule Rouge (Labex GR-Ex), PRES Sorbonne, Paris, France.
⁷ Exploration Fonctionnelle Respiratoire, Médecine du Sport et de l'Activité Physique, Hospices Civils de Lyon, Hôpital Croix Rousse, Lyon, France.
⁸ Molecular Physiology, Center for Integrative Physiology and Molecular Medicine, Saarland University, Homburg, Germany.
⁹ University of Poitiers, MOVE Laboratory UR 20296, Faculté des Sciences du Sport, Poitiers, France.
¹⁰ National School for Mountain Sports, Site of the National School for Skiing and Mountaineering (ENSA), Chamonix, France.
¹¹ Analytical Platform, Stable Isotopes and Cell Biology, Institute of Nutritional Sciences, Justus Liebig University Giessen, Giessen, Germany.
¹² Translational Pneumology, University Hospital Heidelberg, Heidelberg, Germany.

No abstract available

References

1. Alfrey CP, Rice L, Udden MM, Driscoll TB. Neocytolysis: physiological down-regulator of red-cell mass. Lancet. 1997;349(9062):1389-1390.
1. Rice L, Ruiz W, Driscoll T, et al. Neocytolysis on descent from altitude: a newly recognized mechanism for the control of red cell mass. Ann Intern Med. 2001;134(8):652-656.
1. Risso A, Ciana A, Achilli C, Antonutto G, Minetti G. Neocytolysis: none, one or many? A reappraisal and future perspectives. Front Physiol. 2014;5:54.
1. Klein M, Kaestner L, Bogdanova AY, et al. Absence of neocytolysis in humans returning from a 3-week high-altitude sojourn. Acta Physiol. 2021;232(3):e13647.
1. Recktenwald SM, Kaestner L, Bogdanova AY, Minetti G, Klein M, Mairbäurl H. “So is science …”1 : no evidence for neocytolysis on descending the mountains (response to Rice and Gunga). Acta Physiol. 2021;233(3):e13709.