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Review
. 2022 Aug 5;51(4):500-506.
doi: 10.3724/zdxbyxb-2022-0077.

Research progress of mesenchymal stem cell-derived exosomes on inflammatory response after ischemic stroke

Lujia Zhou  1 , Jingyan Liang  1   2 , Tianqing Xiong  1   2
Affiliations
Review

Research progress of mesenchymal stem cell-derived exosomes on inflammatory response after ischemic stroke

Lujia Zhou et al. Zhejiang Da Xue Xue Bao Yi Xue Ban. .

Abstract

Ischemic stroke is characterized by cute onset and high mortality. The suppression of neuroinflammation is crucial in the treatment of ischemic stroke. Exosomes derived from mesenchymal stem cell (MSC) have attracted extensive research attention due to their wide origin, small size, and containing large number of active components. Recent studies have shown that MSC-derived exosomes can inhibit the proinflammatory activity of microglia and astrocytes and stimulate their neuroprotective activity; also can inhibit neuroinflammation by regulating immune cells and inflammatory mediators. This article reviews the roles and related mechanism of MSC-derived exosomes in neuroinflammation after ischemic stroke, hoping to provide ideas and references for the development of a novel approach for the treatment of ischemic stroke diseases.

Keywords: Exosome; Inflammatory mediator; Ischemic stroke; Mesenchymal stem cell; Neuroglial cell; Review.

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Conflict of interest statement

所有作者均声明不存在利益冲突

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