Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2023 May;13(5):e1270.
doi: 10.1002/ctm2.1270.

Stops making sense - For the people?

Affiliations
Editorial

Stops making sense - For the people?

Leoš Shivaya Valášek et al. Clin Transl Med. 2023 May.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare they have no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Unique, one base shorter anticodon stem of tRNATrp CCA is critical for UGA reassignment to tryptophan in a process called stop codon read‐through in Blastocrithidia nonstop. Source: Adapted with permission from magazine Vesmír – vesmir.cz.
FIGURE 2
FIGURE 2
Potential of a modified tRNA molecule to restore synthesis of a full‐length protein such as cystic fibrosis transmembrane conductance regulator (CFTR) and rescue PTC‐caused diseases such as cystic fibrosis. Source: Created with BioRender.com.

References

    1. Brenner S, Jacob F, Meselson M. An unstable intermediate carrying information from genes to ribosomes for protein synthesis. Nature. 1961;190:576‐581. doi:10.1038/190576a0 - DOI - PubMed
    1. Nirenberg M, Leder P. RNA codewords and protein synthesis. The effect of trinucleotides upon the binding of sRNA to ribosomes. Science. 1964;145:1399‐1407. doi:10.1126/science.145.3639.1399 - DOI - PubMed
    1. Shulgina Y, Eddy SR. A computational screen for alternative genetic codes in over 250,000 genomes. Elife. 2021;10:e71402. doi:10.7554/eLife.71402 - DOI - PMC - PubMed
    1. Swart EC, Serra V, Petroni G, Nowacki M. Genetic codes with no dedicated stop codon: context‐dependent translation termination. Cell. 2016;166:691‐702. doi:10.1016/j.cell.2016.06.020 - DOI - PMC - PubMed
    1. Heaphy SM, Mariotti M, Gladyshev VN, Atkins JF, Baranov PV. Novel ciliate genetic code variants including the reassignment of all three stop codons to sense codons in Condylostoma magnum . Mol Biol Evol. 2016;33:2885‐2889. doi:10.1093/molbev/msw166 - DOI - PMC - PubMed

Publication types

LinkOut - more resources